激素性股骨头坏死动物模型构建的研究进展  

Research progress in constructing animal models of steroid-induced osteonecrosis of the femoral head

作　　者：雷阳 李慧英[2] 孟东方[2] 张向北 王凯[1] LEI Yang;LI Huiying;MENG Dongfang;ZHANG Xiangbei;WANG Kai(Henan University of Chinese Medicine,Zhengzhou 450046,China;Zone One Department of Orthopedics and Traumatology,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,郑州450046 [2]河南中医药大学第一附属医院骨伤科一区,郑州450000

出　　处：《中国实验动物学报》2024年第10期1352-1360,共9页Acta Laboratorium Animalis Scientia Sinica

基　　金：河南省中医药科学研究专项(2021JDZY009,2022JDZX123,2023ZY2029)。

摘　　要：激素性股骨头坏死(steroid-induced osteonecrosis of the femoral head,SONFH)作为一种复杂难治性疾病,其发病率逐年上升并呈现出年轻化趋势。良好的疾病动物模型可以为SONFH的发病机制研究和治疗手段开发提供重要的支撑条件,本文通过回顾与整理国内外近年来SONFH动物模型相关的实验研究,从动物选择、造模方法、模型评价等方面归纳和分析SONFH动物模型构建的最新进展,为SONFH的相关研究提供参考。As a complex and refractory disease,the incidence of steroid-induced osteonecrosis of the femoral head(SONFH)is increasing year by year and showing an increasing trend in younger people.A good animal model of disease can provide important support for studying the pathogenesis of SONFH and the development of treatment method.In this paper,the latest progress made in the construction of SONFH animal models is summarized and analyzed from the aspects of animal selection,modeling method,and model evaluation.To achieve this,we review and categorize the experimental studies related to SONFH animal models conducted in China and overseas in recent years,providing a reference for related research of SONFH.

关 键 词：激素性股骨头坏死 动物模型 模型构建 模型评价 造模方法 

分 类 号：Q95-33[生物学—动物学]