高尿酸血症相关基因修饰的动物模型研究进展  

Genetically modified animal models of hyperuricemia

作　　者：路永欣 李佳 谭文彬[1,2] LU Yongxin;LI Jia;TAN Wenbin(Department of Endocrinology,General Hospital of Southern Theater Command of the People’s Liberation Army,Guangzhou 510010,China;the First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]解放军南部战区总医院内分泌科,广州510010 [2]南方医科大学第一临床医学院,广州510515

出　　处：《中国实验动物学报》2024年第10期1361-1368,共8页Acta Laboratorium Animalis Scientia Sinica

基　　金：南部战区总医院科技计划课题(2021NZA001)。

摘　　要：基因敲除技术日益成为建立高尿酸血症(hyperuricemia,HUA)动物模型强有力的工具,HUA相关基因敲除的动物模型不仅有助于揭示尿酸代谢的分子机制,而且对于评估潜在治疗策略具有重要价值。通过查阅国内外文献详细探讨了基因敲除技术在构建HUA动物模型中的应用,重点关注了尿酸氧化酶(urate oxidase,UOX)、葡萄糖转运蛋白9(glucose transporter 9,GLUT9)和ATP结合盒转运体G2(ATP-binding cassette transporter G2,ABCG2)等蛋白的基因在实验动物中的敲除,以期为进一步利用基因敲除技术建立HUA动物模型提供参考和指导。Gene-knockout technology is increasingly used as a powerful tool for establishing animal models of hyperuricemia(HUA).HUA gene-knockout animal models are not only helpful in revealing the molecular mechanisms of uric acid metabolism but are also of great value for evaluating potential therapeutic strategies.In this paper,the application of gene-knockout technology in HUA animal models is discussed in detail by reviewing the domestic and foreign literature,focusing on the knockout of urate oxidase,glucose transporter 9,and ATP-binding cassette transporter G2.The review provides a reference and guidance for the further establishment of HUA animal models by gene knockout technology.

关 键 词：基因敲除 高尿酸血症 动物模型 尿酸氧化酶 葡萄糖转运蛋白9 

分 类 号：Q95-33[生物学—动物学]