成纤维细胞生长因子信号启动机制解析  

Mechanism study of fibroblast growth factors signaling

作　　者：黄志强 付丽丽 陈高帜 李校堃 Huang Zhiqiang;Fu Lili;Chen Gaozhi;Li Xiaokun(School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou 325035,China)

机构地区：[1]温州医科大学药学院,325035

出　　处：《中华内分泌代谢杂志》2024年第10期826-829,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：本文主要介绍了近期发表在Nature的论文《成纤维细胞生长因子激素信号转导的结构基础》的研究设计和主要结果,讨论该研究的科学意义。在代谢性疾病备受关注之时,该研究揭示了成纤维细胞生长因子(FGF)23、FGF受体(FGFR)、Klotho和硫酸乙酰肝素(HS)四元复合物分子机器组装和信号激活模式,为未来糖尿病、慢性肾病等代谢性疾病的研究提供了新的结构信息。This article presents the research design and principal findings of the recent study"Structural basis for FGF hormone signalling"published in Nature.It highlights the study′s significance in elucidating the molecular mechanisms of fibroblast growth factor(FGF)23,FGF receptor(FGFR),Klotho,and heparan sulfate(HS)quaternary complex signalling.These findings offer crucial structural insights that could advance drug discovery for metabolic disorders like diabetes and chronic kidney disease.

关 键 词：代谢性疾病 成纤维细胞生长因子 硫酸乙酰肝素 分子机制 

分 类 号：R589[医药卫生—内分泌]