CD9^(+)CD55^(low)脂肪前体细胞促进2型糖尿病发生  

CD9^(+)CD55^(low)adipose progenitor cells contribute to the development of type 2 diabetes

作　　者：王洪东 杜艳华 黄珊珊 孙喜太[3] 孙海翔[1] 褚薛慧[3] 沈蕾[2] 毕艳[1] Wang Hongdong;Du Yanhua;Huang Shanshan;Sun Xitai;Sun Haixiang;Chu Xuehui;Shen Lei;Bi Yan(Department of Endocrinology,Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing 210008,China;Shanghai Jiao Tong University School of Medicine,Shanghai Institute of Immunology,Shanghai 200025,China;Department of General Surgery,Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院内分泌科,210008 [2]上海交通大学医学院,上海市免疫学研究所200025 [3]南京大学医学院附属鼓楼医院普外科,210008

出　　处：《中华内分泌代谢杂志》2024年第10期830-834,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(82270883,82030026,82070837)。

摘　　要：脂肪前体细胞(APC)是脂肪组织中占比最高的基质细胞,既往被认为处于静默状态且具有明显异质性,但在机体代谢调节中的作用并不清楚。本研究使用单细胞测序等技术,探究了APCs在2型糖尿病发生中的作用。研究发现了CD9+CD55 lowAPCs这一新的亚群,糖尿病时该亚群细胞数量增加,脂肪原位移植该亚群显著损伤受体小鼠的糖稳态,清除该亚群可改善糖尿病小鼠的糖代谢损伤,研究结果为开发新的糖尿病防治手段提供了实验依据。本文已发表于开放获取期刊Nature Communications,2024,15(1):4827。Adipose progenitor cells(APCs)represent a prominent stromal cellular component of adipose tissue and are now identified as highly heterogenous populations.However,the role of APCs in regulating systemic metabolism remains unknown.Using single cell RNA-sequencing,we investigated the role of the APC subpopulations in regulating development of type 2 diabetes.CD9+CD55 low APCs are the novel subset identified in this study,which is significantly increased in type 2 diabetic patients.Transplantation of these cells from type 2 diabetic patients into adipose tissue caused glycemic disturbance in mice.Depletion of pathogenic APCs improved obesity-related glycemic disturbance.Collectively,our data provide deeper insights into human APC functionality and highlights APCs as a potential therapeutic target to combat type 2 diabetes.This study has been published in Nature Communications,2024,15(1):4827.

关 键 词：糖尿病 2型 基质细胞 脂肪前体细胞 单细胞测序 

分 类 号：R587.1[医药卫生—内分泌]