对苯二胺毒性的研究进展  

The research progress on the toxicity of para-phenylenediamine

作　　者：杨婷婷 王霞[1] YANG Tingting;WANG Xia(Center of Reproductive Medicine,Affiliated Hospital of Nantong University,Jiangsu 226001;Medical School of Nantong University)

机构地区：[1]南通大学附属医院生殖医学中心,江苏226001 [2]南通大学医学院

出　　处：《南通大学学报（医学版）》2024年第5期468-472,共5页Journal of Nantong University(Medical sciences)

基　　金：南通市卫生健康委员会研究项目(MB2021005);南通大学附属医院多中心临床研究项目(LCYJB05)。

摘　　要：对苯二胺是苯的衍生物,是一种具有急剧毒性的物质,常被用于制造各种染料。众所周知,对苯二胺对机体的不同部位都具有毒性,包括皮肤、肝脏、肾脏、免疫、生殖及其他。然而,对苯二胺是通过何种机制以及对不同部位造成了怎样的损伤尚不明确。炎症反应和氧化应激在对苯二胺的毒性机制中具有重要作用。本文就对苯二胺的毒性研究作一综述,旨在概述对苯二胺对机体各个部位的毒性作用,并阐明其对各部位毒性作用的具体机制,为对苯二胺的毒理学研究提供新的见解。Para-phenylenediamine is a derivative of benzene and is a rapidly toxic substance,which is commonly used to manufacture various dyes.It is well known that para-phenylenediamine is toxic to different parts of the body including skin,liver,kidney,immunity,reproduction and so on.However,it is still unclear that how and what para-phenylenediamine cause damage to the body.The inflammatory response and oxidative stress play an important role in the toxic mechanism of para-phenylenediamine.Here,the researches on the toxicity induced by para-phenylenediamine were reviewed to provide an overview of the toxic effects of para-phenylenediamine on various parts of the body and elucidate the specific mechanism,which would provide new insights into its toxicological study.

关 键 词：对苯二胺 毒性 炎症 氧化应激 

分 类 号：R595.4[医药卫生—内科学]