干燥综合征的发病机制及治疗研究进展  

Research progress on the pathogenesis and treatment of Sjogren's syndrome

作　　者：石燕楠 徐蕊 钱捷[1] 达展云[1] SHI Yannan;XU Rui;QIAN Jie;DA Zhanyun(Department of Rheumatology and Immunology,Affiliated Hospital of Nantong University,Jiangsu 226001)

机构地区：[1]南通大学附属医院风湿免疫科,江苏226001

出　　处：《南通大学学报（医学版）》2024年第5期473-478,共6页Journal of Nantong University(Medical sciences)

基　　金：南通市科技局课题(MS12021053);南通大学附属医院研究型学科发展基金项目(YJXYY202204-XKB03)。

摘　　要：干燥综合征(Sjogren's syndrome,SS)是一种慢性炎症性自身免疫性疾病,其特征是外分泌腺受累和明显的淋巴细胞浸润,主要表现为口干、眼干,并伴有全身并发症(如肺部疾病、肾损伤、淋巴瘤等)。然而,SS的发病机制和治疗的临床研究相对较少,和其他自身免疫性疾病免疫治疗效果的差异尚不完全清楚。因此,本文就SS的发病机制及治疗进展进行综述,以期为SS的诊疗提供新思路。Sjogren's syndrome(SS)is a chronic inflammatory autoimmune disease characterized by involvement of exocrine glands and significant lymphocyte infiltration.The main manifestations are dry mouth and dry eyes,accompanied by systemic complications(such as lung disease,kidney injury,lymphoma,etc).However,there is relatively little clinical research on the pathogenesis and treatment of SS,and the differences in the efficacy of immunotherapy with other autoimmune diseases are not fully understood.Therefore,this article reviews the pathogenesis and treatment progress of SS,in order to provide new ideas for the diagnosis and treatment of SS.

关 键 词：干燥综合征 辅助性T细胞17 间充质干细胞 B细胞激活因子 

分 类 号：R593.2[医药卫生—内科学]