羰基α位酰氧基化反应研究进展  

Research Progress on Carbonyl Alpha Acylation Reaction

作　　者：吴亚东 赵艳 张慧 陈孟芳 胡开心 王文彬 陈玉滢 包艳琪 王飞 戴一[1] 卫强[1] WU Ya-dong;ZHAO Yan;ZHANG Hui;CHEN Meng-fang;HU Kai-xin;WANG Wen-bin;CHEN Yu-ying;BAO Yan-qi;WANG Fei;DAI Yi;WEI Qiang(Anhui Xinhua University,Hefei 230088,China;Anhui Maternal and Child Health Hospital,Hefei 230001,China)

机构地区：[1]安徽新华学院,安徽合肥230088 [2]安徽省妇幼保健院,安徽合肥230001

出　　处：《安徽化工》2024年第5期1-5,9,共6页Anhui Chemical Industry

基　　金：安徽省高校自然科学研究项目(2023AH051821);安徽省高校自然科学研究项目(2023AH051805);安徽省大学生创新创业训练计划项目(S202312216123)。

摘　　要：酮羰基α位酰氧化合物以及由其可以转化为的α-羟基酮化合物是许多天然产物、生物活性分子以及药物分子的重要构建结构并且也是重要的合成中间体。传统的合成α-羰基酰氧化合物的方法包括α-羰基卤代化合物在碱性条件下与羧酸反应以及碱性羧酸插入到α-重氮甲酮,这些合成α-羰基酰氧化合物大多需要的条件苛刻以及需要加入有毒性的金属氧化剂。阐述了近年来不同的合成α-羰基酰氧化合物方法的研究进展。Ketocarbonyl alpha-acyl oxide compounds and alpha-hydroxyl ketone compounds that can be converted to alpha-hydroxyl ketone compounds are important building blocks of many natural products,bioactive molecules and drug molecules,and they are important synthetic intermediates also.Traditional methods for the synthesis ofα-carbonyl hydroxyl compounds include the reaction ofα-carbonyl halogenated compounds with carboxylic acids under alkaline conditions and the insertion of basic carboxylic acids intoα-diazoketone.Most of these synthesis ofα-carbonyl hydroxyl compounds requires harsh conditions and the addition of toxic metal oxidants.This paper states the different methods for the synthesis ofα-carbonyl oxide have been developed in recent years.

关 键 词：酮羰基 Α位 酰氧化合物 中间体 

分 类 号：TQ463[化学工程—制药化工]