参黄降糖胶囊联合穴位贴敷对2型糖尿病病人胰岛功能及脂联素水平的影响  

Impacts of Shenhuang Jiangtang capsules combined with acupoint application on islet function and adiponectin level in patients with type 2 diabetes mellitus

作　　者：王振强[1] 吕树泉[2] 陈晶晶 张淑芳[3] 赵怡然 苏秀海[2] WANG Zhenqiang;LYU Shuquan;CHEN Jingjing;ZHANG Shufang;ZHAO Yiran;SU Xiuhai(Department of Traditional Chinese Medicine,Cangzhou Hospital of Integrated TCM-WM·Hebei,Cangzhou,Hebei 061000,China;Diabetes Department I,Cangzhou Hospital of Integrated TCM-WM·Hebei,Cangzhou,Hebei 061000,China;Community Clinic,Cangzhou Hospital of Integrated TCM-WM·Hebei,Cangzhou,Hebei 061000,China)

机构地区：[1]河北省沧州中西医结合医院中医内科,河北沧州061000 [2]河北省沧州中西医结合医院糖尿病一科,河北沧州061000 [3]河北省沧州中西医结合医院社区门诊,河北沧州061000

出　　处：《安徽医药》2024年第12期2434-2437,共4页Anhui Medical and Pharmaceutical Journal

基　　金：河北省中医药管理局科研计划项目(2018425)。

摘　　要：目的探究参黄降糖胶囊联合穴位贴敷对2型糖尿病病人胰岛功能及脂联素水平的影响。方法通过随机数字表法将2020年2月至2022年2月河北省沧州中西医结合医院接收的200例气阴两虚型2型糖尿病病人分为对照组(n=100,强化生活方式干预+二甲双胍肠溶片)和研究组(n=100,强化生活方式干预+二甲双胍肠溶片+参黄降糖胶囊和穴位贴敷)。比较两组病人临床治疗效果、胰岛功能指标、脂联素水平、中医证候积分、脂代谢水平。结果研究组总有效率(90.00%,90/100)高于对照组(79.00%,79/100)(P<0.05)。治疗后,研究组和对照组病人胰岛素抵抗指数(HOMA-IR)较治疗前降低(P<0.05),研究组低于对照组(2.51±0.48比2.99±0.59,P<0.05);空腹胰岛素(FINS)、HOMA-β较治疗前升高(P<0.05),研究组高于对照组[(11.92±1.46)mIU/L比(8.47±1.88)mIU/L,124.86±35.96比69.55±21.35;P<0.05]。治疗后,研究组和对照组病人脂联素水平较治疗前升高(P<0.05),研究组高于对照组[(19.04±5.37)mg/L比(16.02±5.58)mg/L,P<0.05]。治疗后,研究组和对照组病人中医证候积分较治疗前降低(P<0.05),研究组低于对照组(P<0.05)。治疗后,研究组和对照组病人总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)较治疗前降低(P<0.05),研究组低于对照组(P<0.05)。结论参黄降糖胶囊联合穴位贴敷对2型糖尿病病人临床治疗效果显著,可改善胰岛功能、脂联素水平和脂代谢水平,减轻临床症状。Objective To explore the impacts of Shenhuang Jiangtang capsules combined with acupoint application on islet function and adiponectin level in patients with type 2 diabetes mellitus(T2DM).Methods Two hundred T2DM patients with deficiency of qi and yin who were admitted to Cangzhou Hospital of Integrated TCM-WM·Hebei from February 2020 to February 2022 were assigned into two groups:the control group(n=100,intensive lifestyle intervention+metformin enteric-coated tablets)and the study group(n=100,intensive lifestyle intervention+metformin enteric-coated tablets+Shenhuang Jiangtang capsules and acupoint application)by means of a random number table.Comparison was made of clinical efficacy,islet function indexes,adiponectin levels,Chinese medicine syndrome scores,and lipid metabolism levels between the two groups of patients.Results The total effective rate in the study group(90.00%,90/100)was higher than that in the control group(79.00%,79/100)(P<0.05).After treatment,the insulin resistance indexes(HOMA-IR)of patients in both groups were lower than those before treatment(P<0.05),and the index in the study group was lower than that in the control group(2.51±0.48 vs.2.99±0.59,P<0.05).Fasting insulin(FINS)and HOMA-βwere higher than those before treatment(P<0.05),and the levels in the study group were higher than those in the control group[(11.92±1.46)mIU/L vs.(8.47±1.88)mIU/L,124.86±35.96 vs.69.55±21.35;P<0.05].After treatment,adiponectin levels were elevated in patients of both groups compared with those before treatment(P<0.05),and the levels were higher in the study group than the control group[(19.04±5.37)mg/L vs.(16.02±5.58)mg/L,P<0.05].After treatment,Chinese medicine syndrome scores in both groups decreased(P<0.05);the score in the study group was lower than that in the control group(P<0.05).The levels of total cholesterol(TC),triacylglycerol(TG),and low density lipoprotein cholesterin(LDL-C)of patients in the study group and the control group after treatment were lower than those before treatment(P<0.

关 键 词：糖尿病 2型 参黄降糖胶囊 穴位贴敷 脂联素 胰岛功能 

分 类 号：R259[医药卫生—中西医结合]