赖氨肌醇维B_(12)联合复方消化酶对功能性消化不良病儿胃肠动力、营养指标、胰岛素样生长因子Ⅰ水平的作用  

Effects of lysine,inosite and vitamin B_(12) oral solution combined with compound digestive enzyme capsules on gastrointestinal motility,nutritional indices,and insulin-like growth factorⅠlevels in children with functional dyspepsia

作　　者：李杏红 李衡 LI Xinghong;LI Heng(Department of Pediatrics,The Third People's Hospital of Shangqiu,Shangqiu,He'nan 476000,China;Department of Pediatrics,The First People's Hospital of Shangqiu,Shangqiu,He'nan 476000,China)

机构地区：[1]商丘市第三人民医院儿内科,河南商丘476000 [2]商丘市第一人民医院儿内科,河南商丘476000

出　　处：《安徽医药》2024年第12期2520-2525,共6页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨赖氨肌醇维B_(12)联合复方消化酶对功能性消化不良(FD)病儿胃肠动力、营养指标、胰岛素样生长因子Ⅰ(IGF-Ⅰ)水平的影响。方法根据治疗方案不同将2021年2月至2023年2月商丘市第三人民医院收治的84例FD病儿分为两组,各42例。对照组予以复方消化酶治疗,观察组予以赖氨肌醇维B_(12)联合复方消化酶治疗,均治疗4周。观察两组疗效、不良反应及治疗前后胃肠动力学指标、胃肠激素[胃动素、生长抑素(SS)]及5-羟色胺(5-HT)水平、营养指标[前白蛋白(PA)、白蛋白、转铁蛋白(TRF)]、免疫指标[免疫球蛋白(Ig)A、IgG、IgM]及IGF-Ⅰ水平变化。结果观察组总有效率97.62%(41/42)较对照组80.95%(34/42)高(P<0.05);治疗2周、4周后观察组胃窦收缩幅度[治疗2周后:(51.65±5.00)mm比(48.32±3.85)mm]、胃窦收缩频率、餐后3 h胃排空率、餐后3 h肠排空率均高于对照组(P<0.05);治疗2周、4周后观察组胃动素、5-HT水平较对照组升高,SS水平较对照组降低(P<0.05);治疗2周、4周后观察组血清白蛋白[治疗2周后:(39.20±4.13)g/L比(36.68±5.65)g/L]、PA、TRF、IGF-Ⅰ[治疗2周后:(112.57±14.20)μg/L比(76.12±11.58)μg/L]水平高于对照组(P<0.05);治疗2周、4周后观察组IgA、IgG、IgM水平高于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论赖氨肌醇维B_(12)联合复方消化酶能改善FD病儿胃肠动力,调节胃肠道激素水平,改善病儿营养状态,提高机体免疫水平,效果确切。Objective To investigate the effects of lysine,inosite and vitamin B_(12) oral solution combined with compound digestive enzyme capsules on gastrointestinal motility,nutritional indices,and insulin-like growth factorⅠ(IGF-Ⅰ)levels in children with functional dyspepsia(FD).Methods Eighty-four children with FD admitted to The Third People's Hospital of Shangqiu City from February 2021 to February 2023 were assigned into two groups,42 cases in each group,according to different therapies.The control group was treated with compound digestive enzyme capsules,while the observation group was treated with lysine,inosite and vitamin B_(12) oral solution combined with compound digestive enzyme capsules,both for 4 weeks.The efficacies and adverse reactions of the two groups were observed,as well as the changes in gastrointestinal dynamics,gastrointestinal hormones[motilin,somatostatin(SS)],5-hydroxytryptamine(5-HT)levels,nutritional indices[prealbumin(PA),albumin(ALB),transferrin(TRF)],immune indicators[immunoglobulin(Ig)A,IgG,IgM],and IGF-Ⅰlevels before and after treatment.Results The total effective rate of the observation group was 97.62%(41/42),which was higher than that of the control group(80.95%,34/42).After 2 and 4 weeks of treatment,the observation group had higher gastric antral contraction amplitude[after 2 weeks of treatment:(51.65±5.00)mm vs.(48.32±3.85)mm],gastric antral contraction frequency,3-hour postprandial gastric emptying rate,and 3-hour postprandial intestinal emptying rate than the control group(P<0.05),and the observation group had higher levels of motilin and 5-HT and lower levels of SS than the control group(P<0.05).After 2 and 4 weeks of treatment,the serum levels of ALB[after 2 weeks of treatment:(39.20±4.13)g/L vs.(36.68±5.65)g/L],PA,TRF,and IGF-Ⅰ[after 2 weeks of treatment:(112.57±14.20)μg/L vs.(76.12±11.58)μg/L]in the observation group were higher than those in the control group(P<0.05);the levels of IgA,IgG,and IgM in the observation group were higher than those in the control

关 键 词：消化不良 复方消化酶 赖氨肌醇维B_(12) 胃肠动力学 5-羟色胺 胰岛素样生长因子Ⅰ 免疫球蛋白 

分 类 号：R725.7[医药卫生—儿科]