25-(OH)D_(3)、IGF-1及补体C3对过敏性紫癜患儿疾病进展的预测分析  

Predictive analysis of 25-(OH)D_(3),IGF-1 and complement C3 on progression in children patients with Henoch-Sch nlein purpura

作　　者：沈坚强[1] 胡月媛[1] 孙明月 杨磊[1] SHEN Jianqiang;HU Yueyuan;SUN Mingyue;YANG Lei(Department of Pediatrics,Changzhou Municipal Wujin Hospital of Traditional Chinese Medicine,Changzhou,Jiangsu 213161,China)

机构地区：[1]常州市武进中医医院儿科,江苏常州213161

出　　处：《重庆医学》2024年第22期3396-3400,共5页Chongqing Medical Journal

基　　金：江苏省卫生健康委员会妇幼健康科研项目(F202058)。

摘　　要：目的分析25-羟维生素D_(3)[25-(OH)D_(3)]、胰岛素样生长因子1(IGF-1)及补体C3、水平在过敏性紫癜患儿中的表达情况及其对患儿疾病进展的预测效能分析。方法选取2018年6月至2023年6月该院收治的102例过敏性紫癜患儿作为研究对象纳入观察组,根据严重程度分为轻度组(35例),中度组(41例),以及重度组(26例)。另将同期体检的50例健康儿童作为对照组。比较各组别血清25-(OH)D_(3)、IGF-1及补体C3的表达水平差异,及其与疾病严重程度的相关性。采用logistic回归分析确定过敏性紫癜患儿疾病进展的影响因素,并通过受试者工作特征(ROC)曲线评估25-(OH)D_(3)、IGF-1及补体C3在过敏性紫癜患儿疾病进展中的预测价值。结果观察组25-(OH)D_(3)、补体C3水平均低于对照组(P<0.05),IGF-1水平高于对照组(P<0.05)。重度组患儿的25-(OH)D_(3)、补体C3水平均低于轻度组与中度组,且中度组低于轻度组(P<0.05);重度组患儿的IGF-1水平高于轻度组与中度组,且中度组高于轻度组(P<0.05)。Spearman相关分析结果显示,25-(OH)D_(3)、补体C3水平与疾病严重程度存在负相关(r=-0.375、-0.576,P<0.05),IGF-1水平与疾病严重程度存在正相关(r=0.866,P<0.05)。ROC曲线分析结果显示,25-(OH)D_(3)、补体C3、IGF-1水平联合检测对患儿疾病进展的预测的AUC最大(0.888),灵敏度为81.4%,特异度为82.0%,Youden指数为0.634。结论25-(OH)D_(3)、IGF-1及C3在综合评估过敏性紫癜患儿疾病进展方面具有较高的灵敏度和特异度,对于过敏性紫癜患儿的疾病进展的风险评估具有较高的临床价值。Objective To analyze the expression levels of 25-hydroxyvitamin D_(3)[25-(OH)D_(3)],insulin-like growth factor 1(IGF-1)and complement C3 in children patients with Henoch-Sch nlein purpura(HSP)and their predictive efficiency on disease progression.Methods A total of 102 children patients with HSP admitted and treated in this hospital from June 2018 to June 2023 were selected as the study subjects and included in the observation group.They were divided into the mild group(35 cases),moderate group(41 cases)and severe group(26 cases)according to the severity degree.Additionally,50 healthy children undergoing physical examination during the same period served as the control group.The differences in serum 25-(OH)D_(3),IGF-1 and complement C3 levels were compared among the groups,as well as their correlations with the disease severity.Logistic regression analysis was used to determine the influencing factors of disease progression in children patients with HSP,and the value of 25-(OH)D_(3),IGF-1 and complement C3 in predicting disease progression was assessed by using the receiver operating characteristic(ROC)curve.Results The levels of 25-(OH)D_(3) and C3 in the observation group were lower than those in the control group,while the level of IGF-1 was higher than that in the control group(P<0.05).The levels of 25-(OH)D_(3) and C3 in the severe group were lower than those in the mild group and moderate group,moreover the moderate group was lower than the mild group(P<0.05).The level of IGF-1 in the severe group was higher than that in the mild group and moderate group,moreover the moderate group was higher than the mild group(P<0.05).The Spearman correlation analysis results indicated that the levels of 25-(OH)D_(3) and complement C3 were negatively correlated with disease severity(r=-0.375,-0.576,P<0.05),while the level of IGF-1 was positively correlated with the disease severity(r=0.866,P<0.05).The ROC curve analysis results revealed that the area under the curve(AUC)of the combined detection of 25-(OH)D_(3),complement

关 键 词：25-羟维生素D_(3) 胰岛素样生长因子1 补体C3 过敏性紫癜 预测效能 

分 类 号：R725.9[医药卫生—儿科]