A core–shell-structured zeolitic imidazolate framework@cationic antimicrobial agent templated silica nanocomposite for tackling antibiotic resistant bacteria infection  

作　　者：Qihui Kan Yaping Song Yining Yao Jun Zhang He Xian Dan Cheng Yue Wang Liang Mao Meiyan Wang Chengzhong Yu 

机构地区：[1]State Key Laboratory of Pollution Control and Resource Reuse,School of the Environment,Nanjing University,Nanjing,China [2]Australian Institute for Bioengineering and Nanotechnology,The University of Queensland,Brisbane,Queensland,Australia [3]School of Chemistry and Molecular Engineering,East China Normal University,Shanghai,P.R.China [4]School of Life Sciences,East China Normal University,Shanghai,P.R.China

出　　处：《Aggregate》2024年第3期397-408,共12页聚集体（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Number:32171414;Natural Science Foundation of Shanghai,Grant/Award Number:23ZR1419500;Nature Science Foundation of Chongqing,Grant/Award Number:CSTB2022NSCQ-MSX0461。

摘　　要：Bacterial infection is a major threat to public health.Nanotechnology offers a solu-tion by combining nanomaterials with antibacterial agents.The development of an effective nanocomposite against drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)is highly important yet challenging.Here,an anti-MRSA core–shell structure is designed,containing antibacterial zeolitic imidazolate framework-8(ZIF-8)as the core and bactericidal benzalkonium chloride(BAC)templated rough-surface mesostructured silica nanocomposite(RMSN)as the shell.The resultant ZIF-8@RMSN nanocomposite exhibits sustained release of BAC and zinc ions,effective disruption of the bacterial membrane,generation of oxidative damage of bacterial DNA,leakage of intracellular components,andfinally bacte-rial death.Furthermore,the synergistic antibacterial mechanisms lead to enhanced biofilm elimination performance.In addition,the ZIF-8@RMSN-modified band-aid effectively combats MRSA infection in vivo.This work has provided a promising nanocomposite against MRSA-related infections.

关 键 词：benzalkonium chloride core–shell structure mesoporous silica metal organic framework methicillin-resistant Staphylococcus aureus 

分 类 号：O62[理学—有机化学]