Aggregation-based analytical chemistry in point-of-care nanosensors  

作　　者：Yuechun Li Zhaowen Cui Lunjie Huang Daohong Zhang Yizhong Shen Jie Cheng Jianlong Wang 

机构地区：[1]College of Food Science and Engineering,Northwest A & F University,Yangling,Shaanxi,China [2]College of Biomass Science and Engineering,Sichuan University,Chengdu,China [3]School of Food & Biological Engineering,Key Laboratory for Agricultural Products Processing of Anhui Province,Hefei University of Technology,Hefei,China [4]Institute of Quality Standards and Testing Technologies for Agro-Products,Chinese Academy of Agricultural Sciences,Beijing,China

出　　处：《Aggregate》2024年第5期23-85,共63页聚集体（英文）

基　　金：National Key Research and Development Program of China,Grant/Award Numbers:2023YFE0103300,2021YFD1700300;National Natural Science Foundation of China,Grant/Award Number:22176047;innovative Talent Promotion Program—Science&Technology Innovation Team of Shaanxi,Grant/Award Number:2023-CX-TD-55;Qinchuangyuan“Scientist+Engineer”team of Shaanxi,Grant/Award Number:2022KXJ-070;Qinghai Special Project of Innovation Platform for Basic Conditions of Scientific Research of China,Grant/Award Number:2022-ZJ-Y18。

摘　　要：It is crucial to realize the point-of-care(POC)testing of harmful analytes,capa-ble of saving limited agricultural resources,assisting environmental remediation,ensuring food safety,and enabling early disease diagnosis.Compared with other conventional POC sensing strategies,aggregation-based analytical chemistry facil-itates the practical-oriented development of POC nanosensors by altering the aggregation status of nanoprobes through the action of multiple aggregation-induced“forces”originating from the targets.Herein,we have proceeded with a comprehensive review focusing on the aggregation-based analytical chemistry in POC nanosensors,covering aggregation-induced“forces”,aggregation-induced signal transductions,aggregation-induced POC nanosensing strategies,and their applications in biomolecular monitoring,food safety analysis,and environmental monitoring.Finally,challenges existing in practical applications have been fur-ther proposed to improve their sensing applications,and we expect our review can speed up the development of cost-effective,readily deployable,and time-efficient nanosensors through aggregation-based analytical chemistry.

关 键 词：aggregation-based analytical chemistry biomolecular monitoring environmental monitoring food safety analysis point-of-care nanosensors 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]