MXene confined microcapsules for uremic toxins elimination  

作　　者：Xiaomin Ye Chaoyu Yang Li Wang Qihui Fan Luoran Shang Fangfu Ye 

机构地区：[1]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,Zhejiang,China [2]School of Chemical Sciences,University of Chinese Academy of Sciences,Beijing,China [3]Beijing National Laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of Sciences,Beijing,China [4]Shanghai Xuhui Central Hospital,Zhongshan-Xuhui Hospital,the Shanghai Key Laboratory of Medical Epigenetics,the International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology),Institutes of Biomedical Sciences,Fudan University,Shanghai,China

出　　处：《Aggregate》2024年第4期236-244,共9页聚集体（英文）

基　　金：National Key Research and Development Program of China,Grant/Award Number:2020YFA0908200;Strategic Priority Research Program of Chinese Academy of Sciences,Grant/Award Number:XDB33030300;National Natural Science Foundation of China,Grant/Award Number:32271383;Youth Innovation Promotion Association of CAS,Grant/Award Number:2021007。

摘　　要：Adsorbents with high adsorption efficiency and excellent biosafety for biomedical applications are highly required.MXene is a promising candidate owning these advantages,yet pristine MXene faces dilemmas including insufficient utility of sur-face site as well as limited processibility.Here,we develop MXene-encapsulated porous microcapsules via microfluidics.The microcapsules have a biomass hydrogel shell that provides robust support for MXene in the core,by which the microcapsules are endowed with high MXene dosage and remarkable biosafety.Additionally,the MXene nanoflakes assemble into a three-dimensional network via metal ion-induced gelation,thereby avoiding restacking and significantly improving surface utiliza-tion.Moreover,a freeze-pretreatment of the microcapsules during preparation results in the formation of a macroporous structure in the shell,which can facilitate the diffusion of the target molecules.These features,combined with additional magneto-responsiveness rendered by the incorporation of magnetic nanoparticles,contribute to prominent performances of the microcapsules in cleaning uremia toxins including creatinine,urea,and uric acid.Thus,it is anticipated that the MXene-encapsulated microcapsules will be promising adsorbents in dialysis-related applications,and the combination of microfluidic encapsulation with metal ion gelation will provide a novel approach for construction of hybrid MXene materials with desired functions.

关 键 词：ADSORPTION MICROCAPSULES MICROFLUIDICS MXene uremic toxins 

分 类 号：O64[理学—物理化学]