子宫肌瘤患者血清白细胞介素表达水平变化及对疾病预后的相关性预测价值  

Changes in serum interleukin expression levels in patients with uterine fibroids and the predictive value of correlation on disease prognosis

作　　者：何方 胡罗娜 HE Fang;HU Luona(Department of Outpatient,The Second Affiliated Hospital of Air Force Military Medical University,Xi'an 71oooo,China;Department of Obstetrics and Gynaecology,The Second Affiliated Hospital of Air Force Military Medical University,Xi'an 71oooo,China)

机构地区：[1]空军军医大学第二附属医院门诊部,陕西西安710000 [2]空军军医大学第二附属医院妇产科,陕西西安710000

出　　处：《中国实验诊断学》2024年第11期1301-1305,共5页Chinese Journal of Laboratory Diagnosis

摘　　要：目的 探讨子宫肌瘤患者血清白细胞介素表达水平变化及对疾病预后的相关性预测价值。方法 回顾性分析2020年1月至2023年12月收治于空军军医大学第二附属医院的子宫肌瘤患者共104例。根据患者子宫肌瘤剔除术后3个月内是否出现子宫肌瘤复发将患者划分为预后良好组(n=80)和疾病复发组(n=24)。对比两组患者基础临床资料及术前、术后血清白细胞介素2(IL-2)、白细胞介素(IL-6)、白细胞介素(IL-8)及白细胞介素(IL-10)的表达水平。对于存在差异的指标进一步通过Spearman相关性分析及二元Logistic回归分析筛选出子宫肌瘤患者术后疾病复发的危险因素,并通过受试者工作曲线(ROC)检测各危险因素独立及联合预测疾病复发的价值。结果 疾病复发组患者子宫肌瘤数目显著高于预后良好组患者,术后药物辅助治疗比例显著低于预后良好组患者(P<0.05),其余基础临床资料对比均无显著差异(P>0.05)。手术后两组患者血清IL-2均显著降低,血清IL-6、IL-8及IL-10均显著升高,且疾病复发组患者各血清白细胞介素水平变化更明显(P<0.05)。Spearman相关性分析表明子宫肌瘤患者子宫肌瘤数目、术后血清IL-6、IL-8及IL-10水平与患者子宫肌瘤复发呈正相关性(P<0.05),患者术后药物辅助治疗及术后血清IL-2水平与患者子宫肌瘤复发呈负相关性(P<0.05)。二元Logistic回归分析则筛选出患者子宫肌瘤数目较多与术后血清IL-8水平升高是子宫肌瘤术后患者疾病复发的独立危险因素,而术后血清IL-2水平升高是子宫肌瘤术后患者疾病复发的保护因素(P<0.05)。ROC分析表明血清IL-8对患者术后疾病复发的独立预测价值最高(曲线下面积为0.659,P<0.05)。结论 子宫肌瘤患者术后疾病复发与患者子宫肌瘤数目、术后血清IL-2、IL-8及IL-10水平存在相关性,其中子宫肌瘤数目、术后血清IL-2及IL-8水平均是疾病复发的危险因素,对于�Objective To investigate the changes in serum interleukin expression levels in patients with uterine fibroids and the correlation predictive value on disease prognosis.Methods A total of 104 patients with uterine fibroids admitted to the Second Affiliated Hospital of Air Force Military Medical University from January 2020 to December 2023 were retrospectively analysed.The patients were divided into a good prognosis group(n=80) and a disease recurrence group(n=24) based on whether they developed fibroid recurrence within 3 months after myomectomy.The basic clinical data and preoperative and postoperative serum interleukin 2(IL-2),interleukin(IL-6),interleukin(IL-8) and interleukin(IL-10) expression levels were compared between the two groups.The risk factors for disease recurrence after surgery for uterine fibroids patients were further screened by Spearman correlation analysis and binary logistic regression analysis for those indicators with differences, and the value of independent and combined prediction of disease recurrence for each risk factor was tested by receiver operating characteristic(ROC).Results The number of uterine fibroids in the disease recurrence group was significantly higher than that in the good prognosis group, and the proportion of postoperative medication-assisted therapy was significantly lower than that in the good prognosis group(P<0.05),and there was no significant difference in the comparison of the rest of the basic clinical data(P>0.05).Serum IL-2 was significantly lower and serum IL-6,IL-8 and IL-10 were significantly higher in both groups after surgery, and the changes in serum interleukin levels were more pronounced in the recurrent disease group(P<0.05).Spearman's correlation analysis showed that the number of fibroids, postoperative serum IL-6,IL-8 and IL-10 levels were positively correlated with the recurrence of fibroids in patients with uterine leiomyomas(P<0.05),while postoperative medication-assisted therapy and postoperative serum IL-2 levels were negatively correlated wi

关 键 词：子宫肌瘤 子宫肌瘤剔除术 白细胞介素 疾病复发 

分 类 号：R246.3[医药卫生—针灸推拿学]