基于图论分析的抑郁症与赌博行为相关性分析  

Correlation analysis between depression and gambling behavior using graph theory

作　　者：马宁欣 王瑜[1] 肖洪兵[1] 邢素霞[1] 徐冉[1] MA Ningxin;WANG Yu;XIAO Hongbing;XING Suxia;XU Ran(School of Computer and Artificial Intelligence,Beijing Technology and Business University,Beijing 100048,China)

机构地区：[1]北京工商大学计算机与人工智能学院,北京100048

出　　处：《中国医学物理学杂志》2024年第11期1374-1382,共9页Chinese Journal of Medical Physics

基　　金：北京市自然科学基金-北京市教育委员会科技计划重点项目(KZ202110011015)。

摘　　要：探究抑郁症患者脑网络的全局属性和局部属性与赌博行为学量表的相关性。对24名赌博行为抑郁症患者和24名健康对照组的任务态脑功能磁共振成像数据进行分析,利用SPM软件对数据进行预处理,采用图论分析方法,构建功能脑网络,计算脑网络的局部属性和全局属性。将不同病程抑郁症组(重度抑郁症患者8例、中度抑郁症患者8例及轻度抑郁症患者8例)和健康对照组的局部属性指标节点度和节点效率进行连边分析,并对比不同病程抑郁症组和健康对照组全局属性指标的变化,最后将全局属性中的小世界属性、全局效率、局部效率分别与赌博行为相关评分量表进行相关性分析。对抑郁症组和健康对照组进行双样本t检验,得到脑区之间的显著性连接(P<0.05),脑网络全局属性指标与不同行为学量表之间存在显著的负相关性,充分验证了赌博行为与抑郁症存在相关性,为探讨个体行为属性和抑郁症的相关性研究提供科学依据,进而辅助抑郁症患者的临床诊断和治疗。The correlations of global/local properties of brain networks with gambling behavioral scales in depression are explored.The task-state brain functional magnetic resonance imaging data of 24 patients with gambling behavior and depression and 24 healthy controls are analyzed,and preprocessed by SPM software.Graph theory analysis method is used to establish the functional brain networks in which local and global properties are calculated.Two sets of local attribute index including node degree and node efficiency are used to make edge analysis in different depression groups(major,moderate and mild depression groups,with 8 patients in each group) and healthy control group,and the changes in global properties are also discussed.Additionally,the correlations of scoring scale related to gambling behavior with 3 criteria on the global properties(small world attribute,global efficiency and local efficiency) are analyzed.The two-sample t-tests on depression groups and healthy control group confirm the significant connections among brain regions(P<0.05),and reveal the significant negative correlations between the global brain network attribute indexes and different behavioral scales,which fully verifies the correlation between gambling behavior and depression,and provides the basis for further exploring correlation between the individual behavior attribute and depression,thereby assisting clinical diagnosis and treatment of depression patients.

关 键 词：抑郁症 功能脑网络 功能磁共振成像 图论分析 

分 类 号：R318[医药卫生—生物医学工程] TP181[医药卫生—基础医学]