广州市越秀区病原学阴性肺结核患者密切接触者筛查结果分析  

Analysis of screening results of close contacts of patients with etiologically negative pulmonary tuberculosis in Yuexiu District,Guangzhou City

作　　者：龚芳[1] 谭守勇[2] 包婉玲[1] 刘国标[1] Gong Fang;Tan Shouyong;Bao Wanling;Liu Guobiao(First Outpatient Service,Guangzhou Chest Hospital,Guangzhou 510095,China;State Key Laboratory of Respiratory Diseases,Guangzhou Chest Hospital,Guangzhou 510095,China)

机构地区：[1]广州市胸科医院一分所,广州510095 [2]广州市胸科医院国家呼吸疾病重点实验室,广州510095

出　　处：《中国防痨杂志》2024年第12期1485-1489,共5页Chinese Journal of Antituberculosis

基　　金：广州市卫生健康科技一般引导项目(20241A010034)。

摘　　要：目的:分析广州市越秀区病原学阴性肺结核患者密切接触者筛查情况,为病原学阴性肺结核患者密切接触者筛查和管理工作提供依据。方法:收集2019年1月1日至2022年12月31日在广州市越秀区结核病防治机构诊断的645例病原学阴性肺结核登记的1149名密切接触者(以下简称病原阴性接触组)筛查结果。以同期登记的920例病原学阳性肺结核患者的1780名密切接触者(以下简称病原阳性接触组)作为对照,比较两组密切接触者筛查情况。结果:病原学阴性指示病例645例,登记密切接触者1149名;密切接触者中男性534名,女性615名,检出肺结核患者45例(3.92%)。病原学阳性指示病例920例,登记密切接触者1780名;密切接触者中男性804名,女性976名,检出肺结核患者52例(2.92%)。两组密切接触者肺结核检出率差异无统计学意义(χ^(2)=2.159,P=0.142)。病原学阴性接触组有可疑症状者27例(2.35%),检出肺结核19例(70.37%);无可疑症状者1122名(97.65%),检出肺结核26例(2.32%)。病原学阳性接触组有可疑症状者42例(2.36%),检出肺结核25例(59.52%);无可疑症状者1738名(97.64%),检出肺结核27例(1.55%),两组接触者中有可疑症状者的结核病检出率均高于无症状接触者,差异均有统计学意义(χ^(2)=324.482,P=0.000;χ^(2)=465.715,P=0.000)。结论:病原学阴性肺结核密切接触者中可发现肺结核患者。有可疑症状的密切接触者肺结核检出率高于无可疑症状的密切接触者。Objective:To analyze the screening result of close contacts of etiologically negative tuberculosis(TB)patients in Yuexiu District,Guangzhou City,and to provide a basis for the screening and management of those close contacts.Methods:The screening results of 1149 close contacts(hereafter referred to as etiologically negative contact group)of 645 cases of etiologically negative TB registered at the TB control facility in Yuexiu District,Guangzhou City diagnosed from January 1,2019,to December 31,2022,were collected.Another 1780 close contacts of 920 etiologically positive pulmonary TB patients registered during the same period(hereinafter referred to as the etiologically positive contact group)were used as controls to compare the screening result of close contacts in the two groups.Results:Among 1149 close contacts with etiologically negative TB patients(534 male and 615 female),45 TB patients were detected(3.92%).Among 1780 close contacts with etiologically positive TB patients(804 male and 976 female),52 TB patients were detected(2.92%).The difference of TB detection rate was not statistically significant(χ^(2)=2.159,P=0.142).In the etiologically negative contact group,27 cases(2.35%)got suspicious symptoms and 19(70.37%)cases were detected with TB from them,while 1122(97.65%)cases were without suspicious symptoms and 26(2.32%)cases were detected with TB.In the etiologically positive group,there were 42(2.36%)cases with suspicious symptoms and 25(59.52%)cases were detected with TB,while there were 1738(97.64%)cases without suspicious symptoms and 27(1.55%)cases were detected with TB.The TB detection rate was higher among symptomatic contacts than asymptomatic contacts in both groups,with statistically significant differences(χ^(2)=324.482,P=0.000,χ^(2)=465.715,P=0.000).Conclusion:TB can be found in close contacts with etiologically negative TB patients.The possibility of detecting TB in close contacts with suspicious symptoms is higher than in close contacts without suspicious symptoms.

关 键 词：结核 肺 接触者追踪 传染病控制 

分 类 号：R521[医药卫生—内科学] R183.3[医药卫生—临床医学]