非结核分枝杆菌与其他呼吸道病原微生物合并感染的研究进展  

Research progress on co-infection of non-tuberculous mycobacteria and other respiratory pathogens

作　　者：杜姗姗[1] 沙巍[1] 王丽[1] Du Shanshan;Sha Wei;Wang Li(Department of Tuberculosis,Shanghai Pulmonary Hospital,School of Medicine,TongJi University,Shanghai 200433,China)

机构地区：[1]同济大学附属上海市肺科医院结核科,上海200433

出　　处：《中国防痨杂志》2024年第12期1535-1540,共6页Chinese Journal of Antituberculosis

基　　金：科技部重点研发计划(2023YFC2307300);上海市加强公共卫生体系建设三年行动计划(2023—2025)项目(GWVI-9,GWVI-11.1-05)。

摘　　要：随着人口老龄化程度逐年上升,结构性肺病患者不断增多,非结核分枝杆菌肺病(non-tuberculous mycobacteria pulmonary disease,NTM-PD)的发病率呈现增高趋势。大多数NTM-PD患者发病时已存在基础肺病,常同时合并感染多种病原微生物,进一步增加了NTM病诊治和疗效判定的难度,合并感染成为导致NTM-PD治疗成功率低和复发率高的重要原因之一。作者通过检索相关文献,对NTM合并感染的研究进展进行综述,以丰富临床工作者对NTM-PD患者肺部合并感染的认识,研究临床干预策略。With the increasing aging of the population and the growing number of patients with structural lung diseases,the incidence of non-tuberculous mycobacteria pulmonary disease(NTM-PD)is on the rise.Most patients with NTM-PD have pre-existing underlying lung disease and are frequently co-infected with multiple pathogenic microorganisms,which further increases the difficulty of diagnosis and treatment of NTM disease as well as the evaluation of the efficacy of regimen.Co-infection is one of the major reasons for the low therapeutic success rate and high relapse rate.The authors reviewed the research progress of NTM co-infections by searching the relevant literature,in an attempt to enrich the understanding of pulmonary co-infections in patients with NTM-PD and to discuss their clinical intervention strategies.

关 键 词：分枝杆菌感染 非典型性细菌 呼吸道感染 研究 

分 类 号：R56[医药卫生—呼吸系统]