动态监测病毒性肺炎患儿Th1、Th2细胞因子及铁蛋白水平的临床意义  

Clinical Significance of Dynamic Monitoring of Th1,Th2 Cytokines,and Ferritin Levels in Children with Viral Pneumonia

作　　者：刘奇[1] 郭宏丽 李诚 王红艳[1] 李凯歌[1] LIU Qi;GUO Hongli;LI Cheng;WANG Hongyan;LI Kaige(Department of Pediatrics,Honghui Hospital Affiliated to Xi'an Jiaotong University,Xi'an,Shaanxi 710054,China)

机构地区：[1]西安交通大学附属红会医院儿科,陕西西安710054

出　　处：《转化医学杂志》2024年第3期363-366,370,共5页Translational Medicine Journal

基　　金：陕西省科技统筹创新工程计划项目(2022KT ZDSF02-04)。

摘　　要：目的 探究动态监测病毒性肺炎患儿辅助性T细胞1 (Th1)、Th2细胞因子及铁蛋白(SF)水平的临床意义。方法 选取西安交通大学附属红会医院2023年1月至2024年2月114例病毒性肺炎患儿为研究组,另选80名同期来院体检的健康儿童为对照组。所有患儿均接受临床治疗,比较研究组与对照组及研究组治疗前后血清Th1、Th2细胞因子、Th1/Th2及SF水平。根据患儿入院病情严重程度将研究组患儿分为轻症组(n=68)、重症组(n=46),比较2组血清Th1、Th2细胞因子、Th1/Th2及SF水平。采用Spearman相关系数分析血清Th1、Th2细胞因子及SF水平与病毒性肺炎患儿病情的相关性。结果 研究组治疗前血清白细胞介素2 (IL-2)、γ干扰素(IFN-γ)、Th1/Th2水平显著低于对照组,IL-4、IL-10、SF水平显著高于对照组,差异均有统计学意义(均P <0.05);治疗后,研究组血清IL-2、IFN-γ、Th1/Th2水平均显著升高,IL-4、IL-10、SF水平均显著降低(均P <0.05);轻症组血清IL-2、IFN-γ、Th1/Th2水平显著高于重症组,IL-4、IL-10、SF水平显著低于重症组,差异均有统计学意义(均P <0.05);Spearman相关性分析显示,病毒性肺炎患儿病情与血清IL-2、IFN-γ、Th1/Th2呈显著负相关(P <0.05),与IL-4、IL-10、SF水平呈显著正相关(P <0.05)。结论病毒性肺炎患儿Th1细胞因子水平下调,Th2细胞因子水平上调,Th1/Th2失衡,血清SF水平升高,且Th1、Th2细胞因子及SF水平与病情呈显著相关性,Th1、Th2细胞因子及血清SF水平对治疗情况具有一定的评估价值。Objective To explore the clinical significance of dynamic monitoring of helper T cell 1(Th1),Th2 cytokines,and serum ferritin(SF)levels in children with viral pneumonia.Methods 114 children with viral pneumonia in Honghui Hospital Affiliated to Xi'an Jiaotong University from January 2023 to February 2024 were selected as the study group,and 80 healthy children who received physical examination during the same period were included in the control group.All children received clinical treatment.The levels of serum Th1,Th2 cytokines,Th1/Th2,and SF were compared between the study group and the control group before and after treatment.According to the disease severity of children at admission,the children in the study group were divided into mild group(n=68)and severe group(n=46).The levels of serum Th1 and Th2 cytokines,Th1/Th2,and SF were compared between groups.The Spearman correlation coefficient was used to analyze the correlation between serum Th1,Th2 cytokines and SF levels and the severity of viral pneumonia in children.Results The levels of serum IL-2,IFN-γ,and Th1/Th2 in the study group were significantly lower than those in the control group,while the levels of IL-4,IL-10,and SF were significantly higher than those in the control group(P<0.05).After treatment,the levels of serum IL-2,IFN-γ,and Th1/Th2 were significantly increased,while the levels of IL-4,IL-10,and SF were significantly decreased(P<0.05).Serum IL-2,IFN-γ,and Th1/Th2 levels in the mild group were significantly higher,while IL-4,IL-10,and SF levels were significantly lower compared to the severe group(P<0.05).Spearman correlation analysis showed that the disease condition of children with viral pneumonia was significantly negatively correlated with serum IL-2,IFN-γ,and Th1/Th2(P<0.05),and was significantly positively correlated with IL-4,IL-10,and SF levels(P<0.05).Conclusion The levels of Th1 cytokines in children with viral pneumonia are down-regulated while the Th2 cytokines are up-regulated,Th1/Th2 is imbalanced,and serum SF level is inc

关 键 词：肺炎 病毒性 T细胞 TH1细胞 TH2细胞 铁蛋白质类 数据相关性 

分 类 号：R725.6[医药卫生—儿科]