血清ox-LDL、LH/FSH水平与多囊卵巢综合征不孕症患者治疗结局的关系  

Relationship Between Serum ox-LDL and LH/FSH Levels and Treatment Outcomes in Infertile Patients with Polycystic Ovarian Syndrome

作　　者：鲁俊 刘永红 LU Jun;LIU Yonghong(Department of Obstetrics and Gynecology,Beijing Electric Power Hospital,Beijing 100041,China)

机构地区：[1]国家电网公司北京电力医院妇产科,北京100041

出　　处：《转化医学杂志》2024年第4期532-535,共4页Translational Medicine Journal

基　　金：中华国际科学交流基金会(编号:Z2020LBJ003)。

摘　　要：目的分析血清氧化型低密度脂蛋白(ox-LDL)、促黄体生成素/卵泡刺激素(LH/FSH)水平与多囊卵巢综合征(PCOS)不孕症患者治疗结局的关系。方法选取PCOS不孕症患者160例(PCOS不孕症组),和同期健康女性80例(对照组),根据治疗结局将PCOS不孕症患者分为结局不良组(99例)和结局良好组(61例)。采用酶联免疫吸附法检测ox-LDL水平和计算LH/FSH。以PCOS不孕症患者治疗结局为因变量,多因素非条件Logistic回归分析其影响因素。绘制受试者工作特征(ROC)曲线评价血清ox-LDL、LH/FSH水平对PCOS不孕症患者治疗结局不良的预测效能。结果PCOS不孕症组血清ox-LDL、LH/FSH水平高于对照组(均P<0.05)。160例PCOS不孕症患者治疗结局不良率61.88%(99/160)。结局不良组血清ox-LDL、LH/FSH水平高于结局良好组(P均<0.05)。PCOS不孕症患者治疗结局不良的独立危险因素为稳态模型评估-胰岛素抵抗、ox-LDL、LH/FSH(P<0.05)。血清ox-LDL、LH/FSH水平联合预测PCOS不孕症患者治疗结局不良的曲线下面积大于血清ox-LDL、LH/FSH水平单独预测(均P<0.05)。结论血清ox-LDL、LH/FSH水平升高与PCOS不孕症患者治疗结局不良密切相关,二者联合对其有较高的预测效能。Objective To investigate the relationship between serum oxidized low-density lipoprotein(ox-LDL),luteinizing hormone/follicle-stimulating hormone(LH/FSH)levels,and treatment outcomes in infertile patients with polycystic ovary syndrome(PCOS).Methods A total of 160 infertile patients with PCOS(PCOS infertility group)and 80 healthy women(control group)were selected.The PCOS infertility patients were further divided into a poor outcome group(99 patients)and a good outcome group(61 patients)based on their treatment outcomes.Enzyme-linked immunosorbent assay was used to measure ox-LDL levels and calculate LH/FSH ratios.Multifactorial unconditional logistic regression was employed to determine the influencing factors,using treatment outcomes of PCOS infertility patients as the dependent variable.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive efficiency of serum ox-LDL and LH/FSH levels.Results Serum ox-LDL and LH/FSH levels in the PCOS infertility group were significantly higher than those in the control group(all P<0.05).The poor treatment outcome rate was 61.88%(99/160)among PCOS infertility patients.Serum ox-LDL and LH/FSH levels in the poor outcome group were higher than those in the good outcome group(all P<0.05).Independent risk factors for poor treatment outcomes in PCOS infertility patients included homeostatic model assessment-insulin resistance,ox-LDL,and LH/FSH.The area under the ROC curve(AUC)for predicting poor treatment outcomes using combined serum ox-LDL and LH/FSH levels was greater than that for ox-LDL or LH/FSH alone(all P<0.05).Conclusion Elevated serum ox-LDL and LH/FSH levels are strongly associated with poor treatment outcomes in PCOS infertility patients,and their combination provides high predictive efficacy.

关 键 词：多囊卵巢综合征 不育 女性 氧化型低密度脂蛋白 促黄体激素/卵泡刺激素 治疗结局 Logistic模型 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]