桥本甲状腺炎患者外周血NLR水平及与甲状腺激素和自身抗体的相关性  

Peripheral Blood Nlr Level in Patients with Hashimoto's Thyroiditis and Its Correlation with Thyroid Hormones and Autoantibodies

作　　者：丁朝娟 应喜慧 李娟[1] 白劲松 DING Chaojuan;YING Xihui;LI Juan;BAI Jinsong(Department of Endocrinology,Xindu District Hospital of Traditional Chinese Medicine(Affiliated Hospital of Traditional Chinese Medicine of Chengdu Medical College),Chengdu 610500,China;Department of Clinical Laboratory,Xindu District Hospital of Traditional Chinese Medicine(Affiliated Hospital of Traditional Chinese Medicine of Chengdu Medical College),Chengdu 610500,China)

机构地区：[1]成都市新都区中医医院(成都医学院附属中医院)内分泌科,四川成都610500 [2]成都市新都区中医医院(成都医学院附属中医院)检验科,四川成都610500

出　　处：《转化医学杂志》2024年第4期556-559,575,共5页Translational Medicine Journal

基　　金：四川省中医药管理局科学技术研究专项课题(2023MS022)。

摘　　要：目的探究桥本甲状腺炎(HT)外周血中性粒细胞与淋巴细胞比值(NLR)水平及与甲状腺激素和自身抗体的相关性。方法选取2020年1月至2023年6月成都市新都区中医医院收治的210例HT患者作为HT组,其中甲状腺功能正常为A组,共82例;亚临床甲减为B组,共71例,临床甲减为C组,共57例,并选取同期本院健康体检者102名作为对照组。对比HT组和对照组的一般资料[性别、年龄、体质量指数(BMI)]、血常规指标[血红蛋白(Hb)、总胆固醇(TC)、空腹血糖(FPG)、甘油三酯(TG)、丙氨酸氨基转移酶(ALT)、尿酸(UA)、肌酐(Cr)、中心粒细胞计数(NEUT)、淋巴细胞计数(LYM)和NLR]、甲状腺激素[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)]和甲状腺自身抗体[抗甲球蛋白抗体(TgAb)、过氧化甲状腺酶(TPOAb)]水平,比较各亚组间的NEUT、LYM、NLR、TSH、FT3、FT4、TgAb、TPOAb水平。采用Pearson相关性分析HT患者NLR水平与TSH、FT3、FT3、TgAb以及TPOAb的相关性。结果HT组与对照组的性别、年龄、BMI、Hb、TC、FPG、TG、ALT、UA、Cr比较,差异无统计学意义(P>0.05);NEUT、LYM、NLR水平:HT组>对照组,差异有统计学意义(P<0.05);TSH、TgAb、TPOAb水平:HT组>对照组,FT3、FT4水平:HT组<对照组,差异有统计学意义(均P<0.05);NEUT、LYM、NLR、TSH、TgAb、TPOAb水平:C组>B组>A组,FT3、FT4水平:C组<B组<A组,差异有统计学意义(均P<0.05);Pearson相关分析表明,HT患者NLR水平与TSH、TgAb、TPOAb呈正相关,与FT3、FT4水平呈负相关(P<0.05)。结论HT患者NLR水平较高,且随着甲状腺功能减退相应升高;HT患者NLR与TSH、TgAb、TPOAb水平存在正相关关系,与FT3、FT4水平为负相关关系。临床上监测HT患者外周血NLR有助于病情判断、早期预防和治疗。Objective To explore the peripheral blood neutrophil-to-lymphocyte ratio(NLR)in patients with Hashimoto's thyroiditis(HT)and the correlation with thyroid hormones and autoantibodies.Methods The 210 HT patients admitted to Chengdu Xindu District TCM Hospital from January 2020 to June 2023 were selected as the HT group.Among the patients,82 cases with normal thyroid function were included in group A,71 cases with subclinical hypothyroidism were enrolled as group B and 57 cases with clinical hypothyroidism were set as group C.And 102 patients in our hospital in the same period were selected as the control group.General data comparing the HT and control groups[gender,age,body mass index(BMI)],blood routine indicators[hemoglobin(Hb),total cholesterol(TC),fasting plasma glucose(FPG),triglyceride(TG),alanine aminotransferase(ALT),uric acid(UA),creatinine(Cr),neutrophil count(NEUT),lymphocyte count(LYM),NLR],thyroid hormones[thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4)]and thyroid autoantibodies[anti-thyroglobulin antibody(TgAb),thyroid peroxidase(TPOAb)]levels.The levels of NEUT,LYM,NLR,TSH,FT3,FT4,TgAb,and TPOAb were compared between the subgroups.Pearson correlation analysis was used to explore the correlation between NLR and TSH,FT3,FT3,TgAb and TPOAb in HT patients.Results There were no statistical differences in gender,age,BMI,Hb,TC,FPG,TG,ALT,UA and Cr between HT group and control group(P>0.05).NEUT,LYM,and NLR levels:HT group>control group,statistically significant difference(P<0.05).TSH,TgAb,TPOAb level:HT group>control group,FT3,FT4 level:HT group<control group,statistically significant difference(all P<0.05).NEUT,LYM,NLR,TSH,TgAb and TPOAb were manifested as group C>group B>group A while FT3 and FT4 showed group C<group B<group A,statistically significant difference(all P<0.05).Pearson correlation analysis showed that NLR levels were positively correlated with TSH,TgAb and TPOAb and negatively associated with FT3 and FT4 levels(P<0.05).Conclusion NLR is higher in patients wit

关 键 词：桥本甲状腺炎 中性粒细胞与淋巴细胞比值 甲状腺激素 抗体 

分 类 号：R581.4[医药卫生—内分泌]