兰尼碱受体在阿尔茨海默病中作用机制的研究进展  

Research progress in the mechanism of Ryanodine receptors in Alzheimer’s disease

作　　者：史婷 尹莉芳 秦超 SHI Ting;YIN Li-fang;QIN Chao(Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 211198)

机构地区：[1]中国药科大学药学院药剂系,南京211198

出　　处：《中南药学》2024年第11期3051-3057,共7页Central South Pharmacy

摘　　要：Ca^(2+)作为细胞内重要的调节信号,是维持机体正常生理功能的基础。当Ca^(2+)平衡被打破时,将会导致一系列严重的后果。研究表明,Ca^(2+)在阿尔茨海默病中扮演着至关重要的角色,很可能是造成发病的深层原因。其中,兰尼碱受体(Ryanodine receptors,RyRs)是主要调节Ca^(2+)释放的离子通道。因此,阐明RyRs在阿尔茨海默病中发挥的作用对于寻找合适的治疗方法至关重要。本文从RyRs特征出发,介绍其介导的Ca^(2+)释放与阿尔茨海默病的关系,为将来阿尔茨海默病的药物治疗方案提供思路。As an important regulatory signal in cells,Ca2+is important in maintaining normal physiological function.When the Ca^(2+)balance is broken,many consequences follow.Studies have shown that Ca^(2+)is the likely underlying cause of Alzheimer’s disease.Ryanodine receptors(RyRs)serve as the ion channel that mainly regulate Ca^(2+)release.Elucidating the role that RyRs play in Alzheimer’s disease is critical to finding suitable treatments.Based on the characteristics of RyRs,this paper discussed the relationship between RyRs mediated Ca^(2+)release and Alzheimer’s disease to provide ideas for future treatment.

关 键 词：兰尼碱受体 阿尔茨海默病 CA^(2+) 

分 类 号：R341[医药卫生—基础医学]