A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties  

作　　者：Yunshu Wu Feifei Wang Yao Huang Fu Zheng Yuhao Zeng Zhen Lu Songlin Wang Baoan Sun Yuchun Sun 

机构地区：[1]Center of Digital Dentistry,Peking University School and Hospital of Stomatology,Beijing,100081,China [2]National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,Beijing,100081,China [3]Beijing Key Laboratory of Digital Stomatology,Beijing,100081,China [4]Beijing Laboratory of Oral Health,Capital Medical University,Beijing,100069,China [5]Institute of Physics,Chinese Academy of Sciences,Beijing,100190,China [6]Department of Orthodontics,Peking University School and Hospital of Stomatology,Beijing,100081,China [7]Laboratory of Homeostatic Medicine,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China

出　　处：《Bioactive Materials》2024年第9期25-40,共16页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(52035001);National Key R&D Program of China(2019YFB1706904);Beijing Training Project for the Leading Talents in S&T(Z191100006119022);National Key Research and Development Plan(2018YFA0703603);National Science 535 Foundation of China(52192602);Youth Fund of the National Natural Science Foundation of China(82201125).

摘　　要：Zirconium-based metallic glasses(Zr-MGs)are demonstrated to exhibit high mechanical strength,low elastic modulus and excellent biocompatibility,making them promising materials for endosseous implants.Meanwhile,tantalum(Ta)is also well known for its ideal corrosion resistance and biological effects.However,the metal has an elastic modulus as high as 186 GPa which is not comparable to the natural bone(10–30 GPa),and it also has a relative high cost.Here,to fully exploit the advantages of Ta as endosseous implants,a small amount of Ta(as low as 3 at.%)was successfully added into a Zr-MG to generate an advanced functional endosseous implant,Zr58Cu25Al14Ta3 MG,with superior comprehensive properties.Upon carefully dissecting the atomic structure and surface chemistry,the results show that amorphization of Ta enables the uniform distribution in material surface,leading to a significantly improved chemical stability and extensive material-cell contact regulation.Systematical analyses on the immunological,angiogenesis and osteogenesis capability of the material are carried out utilizing the next-generation sequencing,revealing that Zr_(58)Cu_(25)Al_(14)Ta_(3)MG can regulate angiogenesis through VEGF signaling pathway and osteogenesis via BMP signaling pathway.Animal experiment further confirms a sound osseointegration of Zr_(58)Cu_(25)Al_(14)Ta_(3)MG in achieving better bone-implant-contact and inducing faster periimplant bone formation.

关 键 词：TANTALUM Zirconium-based metallic glass Surface chemistry Atomic structure Endosseous implant 

分 类 号：TG139.8[一般工业技术—材料科学与工程]