Dynamic microphysiological system chip platform for high-throughput,customizable,and multi-dimensional drug screening  

作　　者：Yuxuan Zhu Deming Jiang Yong Qiu Xin Liu Yuhan Bian Shichao Tian Xiandi Wang K.Jimmy Hsia Hao Wan Liujing Zhuang Ping Wang 

机构地区：[1]Biosensor National Special Laboratory,Key Laboratory of Biomedical Engineering of Ministry of Education,Department of Biomedical Engineering,Zhejiang University,Hangzhou,Zhejiang,310027,China [2]Schools of Mechanical&Aerospace Engineering,of Chemical&Biomedical Engineering,Nanyang Technological University,639798,Singapore [3]Cancer Center,Binjiang Institute of Zhejiang University,Hangzhou,310027,China [4]The MOE Frontier Science Center for Brain Science&Brain-machine Integration,Zhejiang University,Hangzhou,310027,China [5]State Key Laboratory of Transducer Technology,Chinese Academy of Sciences,Shanghai,200050,China

出　　处：《Bioactive Materials》2024年第9期59-73,共15页生物活性材料（英文）

基　　金：funded by the National Key Research and Development Program of China(No.2021YFF1200803);National Natural Science Foundation of China(No.62120106004,61901412,62271443);and China Postdoctoral Science Foundation Funded Project(2022M712783).

摘　　要：Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening.By employing diverse types of spheroids or organoids,it is feasible to establish microphysiological systems that enhance the precision of disease modeling and offer more dependable and comprehensive drug screening.High-throughput microphysiological systems that support optional,parallel testing of multiple drugs have promising applications in personalized medical treatment and drug research.However,establishing such a system is highly challenging and requires a multidisciplinary approach.This study introduces a dynamic Microphysiological System Chip Platform(MSCP)with multiple functional microstructures that encompass the mentioned advantages.We developed a high-throughput lung cancer spheroids model and an intestine-liverheart-lung cancer microphysiological system for conducting parallel testing on four anti-lung cancer drugs,demonstrating the feasibility of the MSCP.This microphysiological system combines microscale and macroscale biomimetics to enable a comprehensive assessment of drug efficacy and side effects.Moreover,the microphysiological system enables evaluation of the real pharmacological effect of drug molecules reaching the target lesion after absorption by normal organs through fluid-based physiological communication.The MSCP could serves as a valuable platform for microphysiological system research,making significant contributions to disease modeling,drug development,and personalized medical treatment.

关 键 词：Microphysiological system Organ-on-a-chip Biomimetics High throughput Multidimensional drug screening 

分 类 号：Q811[生物学—生物工程]