Structure-function integrated biodegradable Mg/polymer composites:Design,manufacturing,properties,and biomedical applications  

作　　者：Xianli Wang Cheng Wang Chenglin Chu Feng Xue Jun Li Jing Bai 

机构地区：[1]School of Materials Science and Engineering,Southeast University,Jiangning,Nanjing,211189,Jiangsu,China [2]Jiangsu Key Laboratory for Advanced Metallic Materials,Jiangning,Nanjing,211189,Jiangsu,China [3]Department of Biomedical Engineering,College of Design and Engineering,National University of Singapore,Singapore,119276,Singapore

出　　处：《Bioactive Materials》2024年第9期74-105,共32页生物活性材料（英文）

基　　金：supported by the Science and Technology Project of Jiangsu Province(BE2023719);Suzhou Science and Technology Project(SYC2022135,SJC2023005,SZS2023023);the Open Research Fund of Jiangsu Key Laboratory for Advanced Metallic Materials(AMM2024A01,AMM2023B03);Jiangsu Key Laboratory for Light Metal Alloys(LMA202403);Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology(ASMA202304);Ms.X.Wang thanks the China Scholarship Council for the award of fellowship and fundings(No.202306090175).

摘　　要：Mg is a typical biodegradable metal widely used for biomedical applications due to its considerable mechanical properties and bioactivity.Biodegradable polymers have attracted great interest owing to their favorable processability and inclusiveness.However,it is challenging for the degradation rates of Mg or polymers to precisely match tissue repair processes,and the significant changes in local pH during degradation hinder tissue repair.The concept of combining Mg with polymers is proposed to overcome the shortcomings of materials,aiming to meet repair needs from various aspects such as mechanics and biology.Therefore,it is essential to systematically understand the behavior of biodegradable Mg/polymer composite(BMPC)from the design,manufacturing,mechanical properties,degradation,and biological effects.In this review,we elaborate on the design concepts and manufacturing strategies of high-strength BMPC,the“structure-function”relationship between the microstructures and mechanical properties of composites,the variation in the degradation rate due to endogenous and exogenous factors,and the establishment of advanced degradation research platform.Additionally,the interplay among composite components during degradation and the biological function of composites under nonresponsive/stimuli-responsive platforms are also discussed.Finally,we hope that this review will benefit future clinical applications of“structure-function”integrated biomaterials.

关 键 词：Mechanical property Interface BIODEGRADATION Stimuli-responsiveness Tissue engineering 

分 类 号：TB33[一般工业技术—材料科学与工程] R318[医药卫生—生物医学工程]