A rechargeable coating with temporal-sequence antibacterial activity and soft tissue sealing  

作　　者：Fang Wang Shiwei Guan Min Xing Wenhao Qian Jiajun Qiu Xuanyong Liu 

机构地区：[1]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai,200050,PR China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing,100049,PR China [3]Shanghai Xuhui District Dental Center,Shanghai,200032,PR China [4]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Biological Science and Medical Engineering,Donghua University,Shanghai,201620,PR China

出　　处：《Bioactive Materials》2024年第9期224-238,共15页生物活性材料（英文）

基　　金：supported by National Natural Science Foundation of China(52272283);Key Research and Development Program of Zhejiang Province(2023C03G9103957);Young Elite Scientists Sponsorship Program by CAST(YESS)(2022-2024QNRC001);Youth Innovation Promotion Association CAS(2023263);Major/Key Program of State Key Laboratory for Modification of Chemical Fibers and Polymer Materials(23M1060280).

摘　　要：Transcutaneous implants that penetrate through skin or mucosa are susceptible to bacteria invasion and lack proper soft tissue sealing.Traditional antibacterial strategies primarily focus on bacterial eradication,but excessive exposure to bactericidal agents can induce noticeable tissue damage.Herein,a rechargeable model(HPI-Ti)was constructed using perylene polyimide,an aqueous battery material,achieving temporal-sequence regulation of bacterial killing and soft tissue sealing.Charge storage within HPI-Ti is achieved after galvanostatic charge,and chemical discharge is initiated when immersed in physiological environments.During the early discharge stage,post-charging HPI-Ti demonstrates an antibacterial rate of 99.96±0.01%for 24 h,preventing biofilm formation.Contact-dependent violent electron transfer between bacteria and the material causes bacteria death.In the later discharge stage,the attenuated discharging status creates a gentler electron-transfer microenvironment for fibroblast proliferation.After discharge,the antibacterial activity can be reinstated by recharge against potential reinfection.The antibacterial efficacy and soft tissue compatibility were verified in vivo.These results demonstrate the potential of the charge-transfer-based model in reconciling antibacterial efficacy with tissue compatibility.

关 键 词：Polyimides Medical titanium Transcutaneous implants ANTIBACTERIAL Soft tissue sealing 

分 类 号：TQ460.1[化学工程—制药化工]