Advanced nerve regeneration enabled by neural conformal electronic stimulators enhancing mitochondrial transport  

作　　者：Hao Bai Siqi Zhang Huiran Yang Jing Wang Hongli Chen Jia Li Lin Li Qian Yang Bo Peng Ziyi Zhu Siyuan Ni Keyin Liu Wei Lei Tiger H.Tao Yafei Feng 

机构地区：[1]Department of Orthopedics,Xijing Hospital,The Fourth Military Medical University,Xi’an,710032,China [2]State Key Laboratory of Transducer Technology,Shanghai Institute of Microsystem and Information Technology,Chinese Academy of Sciences,Shanghai,200050,China [3]Key Laboratory of Aerospace Medicine of the Ministry of Education,School of Aerospace Medicine,Fourth Military Medical University,Xi’an,China [4]The Institute of Flexible Electronics(IFE,Future Technologies),Xiamen University,Xiamen,361005,Fujian,China [5]Frontiers Science Center for Flexible Electronics,Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering,Northwestern Polytechnical University,Xi’an,710072,PR China [6]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing,100049,China [7]School of Physical Science and Technology,ShanghaiTech University,Shanghai,200031,China [8]Institute of Brain-Intelligence Technology,Zhangjiang Laboratory,Shanghai,200031,China

出　　处：《Bioactive Materials》2024年第9期287-301,共15页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(82172476,82172393).

摘　　要：Addressing peripheral nerve defects remains a significant challenge in regenerative neurobiology.Autograftsemerged as the gold-standard management,however,are hindered by limited availability and potential neuromaformation.Numerous recent studies report the potential of wireless electronic system for nerve defects repair.Unfortunately,few has met clinical needs for inadequate electrode precision,poor nerve entrapment andinsufficient bioactivity of the matrix material.Herein,we present an advanced wireless electrical nerve stimulator,based on water-responsive self-curling silk membrane with excellent bioabsorbable and biocompatibleproperties.We constructed a unique bilayer structure with an oriented pre-stretched inner layer and a generalsilk membrane as outer layer.After wetting,the simultaneous contraction of inner layer and expansion of outerlayer achieved controllable super-contraction from 2D flat surface to 3D structural reconfiguration.It enablesshape-adaptive wrapping to cover around nerves,overcomes the technical obstacle of preparing electrodes on theinner wall of the conduit,and prevents electrode breakage caused by material expansion in water.The use of forkcapacitor-like metal interface increases the contact points between the metal and the regenerating nerve,solvingthe challenge of inefficient and rough electrical stimulation methods in the past.Newly developed electronicstimulator is effective in restoring 10 mm rat sciatic nerve defects comparable to autologous grafts.The underlyingmechanism involves that electric stimulation enhances anterograde mitochondrial transport to matchenergy demands.This newly introduced device thereby demonstrated the potential as a viable and efficaciousalternative to autografts for enhancing peripheral nerve repair and functional recovery.

关 键 词：Silk materials Electronic stimulator Structural reconfiguration Peripheral nerve regeneration Mitochondrial transport 

分 类 号：R651.3[医药卫生—外科学]