An overview of magnesium-based implants in orthopaedics and a prospect of its application in spine fusion  

作　　者：Xuan He Ye Li Da Zou Haiyue Zu Weishi Li Yufeng Zheng 

机构地区：[1]Department of Orthopaedics,Peking University Third Hospital,No.49 North Huayuan Road,Haidian,Beijing,PR China [2]Department of Rehabilitation Science,The Hong Kong Polytechnic University,Hong Kong SAR,PR China [3]Department of Orthopaedics,The First Affiliated Hospital of Suchow University,PR China [4]Department of Materials Science and Engineering,College of Engineering,Peking University,Comprehensive Scientific Research Building,Beijing,PR China

出　　处：《Bioactive Materials》2024年第9期456-478,共23页生物活性材料（英文）

基　　金：supported by Beijing Municipal Science and Technology Project(Z201100005520073);Key Clinical projects of Peking University Third hospital(BYSY2022064);China Postdoctoral Science Foundation(M2023740146);National Natural Science Foundation of China(82302731).

摘　　要：Due to matching biomechanical properties and significant biological activity,Mg-based implants present great potential in orthopedic applications.In recent years,the biocompatibility and therapeutic effect of magnesiumbased implants have been widely investigated in trauma repair.In contrast,the R&D work of Mg-based implants in spinal fusion is still limited.This review firstly introduced the general background for Mg-based implants.Secondly,the mechanical properties and degradation behaviors of Mg and its traditional and novel alloys were reviewed.Then,different surface modification techniques of Mg-based implants were described.Thirdly,this review comprehensively summarized the biological pathways of Mg degradation to promote bone formation in neuro-musculoskeletal circuit,angiogenesis with H-type vessel formation,osteogenesis with osteoblasts activation and chondrocyte ossification as an integrated system.Fourthly,this review followed the translation process of Mg-based implants via updating the preclinical studies in fracture fixation,sports trauma repair and reconstruction,and bone distraction for large bone defect.Furthermore,the pilot clinical studies were involved to demonstrate the reliable clinical safety and satisfactory bioactive effects of Mg-based implants in bone formation.Finally,this review introduced the background of spine fusion surgeryand the challenges of biological matching cage development.At last,this review prospected the translation potential of a hybrid Mg-PEEK spine fusion cage design.

关 键 词：MAGNESIUM Magnesium alloys Magnesium surface modification Magnesium implants Spine fusion 

分 类 号：R318[医药卫生—生物医学工程]