Functional biomaterials for modulating the dysfunctional pathological microenvironment of spinal cord injury  

作　　者：Dezun Ma Changlong Fu Fenglu Li Renjie Ruan Yanming Lin Xihai Li Min Li Jin Zhang 

机构地区：[1]Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,1 Qiuyang Road,Fuzhou,Fujian,350122,PR China [2]Fujian Key Laboratory of Integrative Medicine on Geriatrics,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian,350122,PR China [3]College of Chemical Engineering,Fuzhou University,2 Xueyuan Road,Fuzhou,350108,PR China [4]Qingyuan Innovation Laboratory,1 Xueyuan Road,Quanzhou,362801,PR China [5]Fujian Children’s Hospital,Fujian Branch of Shanghai Children’s Medical Center,966 Hengyu Road,Fuzhou,350014,PR China [6]Fujian Maternity and Child Health Hospital,111 Daoshan Road,Fuzhou,350005,PR China [7]College of Clinical Medicine for Obstetrics&Gynecology and Pediatrics,Fujian Medical University,111 Daoshan Road,Fuzhou,350005,PR China

出　　处：《Bioactive Materials》2024年第9期521-543,共23页生物活性材料（英文）

基　　金：supported by the National Key R&D Program of China(Grant No.2022YFB3808000/2022YFB3808001);the National Natural Science Foundation of China(Grant Nos.82301554,51903050 and 82104888);Scientific Research Foundation for the High-level Talents Fujian University of Traditional Chinese Medicine(X2021007talents,X2019011talents);School management project of Fujian University of traditional Chinese Medicine(X2023019).

摘　　要：Spinal cord injury(SCI)often results in irreversible loss of sensory and motor functions,and most SCIs are incurable with current medical practice.One of the hardest challenges in treating SCI is the development of a dysfunctional pathological microenvironment,which mainly comprises excessive inflammation,deposition of inhibitory molecules,neurotrophic factor deprivation,glial scar formation,and imbalance of vascular function.To overcome this challenge,implantation of functional biomaterials at the injury site has been regarded as a potential treatment for modulating the dysfunctional microenvironment to support axon regeneration,remyelination at injury site,and functional recovery after SCI.This review summarizes characteristics of dysfunctional pathological microenvironment and recent advances in biomaterials as well as the technologies used to modulate inflammatory microenvironment,regulate inhibitory microenvironment,and reshape revascularization microenvironment.Moreover,technological limitations,challenges,and future prospects of functional biomaterials to promote efficient repair of SCI are also discussed.This review will aid further understanding and development of functional biomaterials to regulate pathological SCI microenvironment.

关 键 词：Spinal cord injury Dysfunctional pathological microenvironment Functional biomaterials Axon regeneration Functional recovery 

分 类 号：R318[医药卫生—生物医学工程]