Smart responsive staple for dynamic promotion of anastomotic stoma healing  

作　　者：Qi Sun Zifeng Yang Ruijun Xu Renjie Li Yang Li Feng Wang Yong Li 

机构地区：[1]School of Medicine,South China University of Technology,Guangzhou,Guangdong,510006,China [2]Department of Gastrointestinal Surgery,Department of General Surgery,Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou,510080,China [3]Guangxi Key Laboratory of Green Chemical Materials and Safety Technology,Guangxi Engineering Research Center for New Chemical Materials and Safety Technology,College of Petroleum and Chemical Engineering,Beibu Gulf University,Qinzhou,535011,China

出　　处：《Bioactive Materials》2024年第9期630-642,共13页生物活性材料（英文）

基　　金：supported by the Leading Innovation Specialist Support Program of Guangdong Province,the National Natural Science Foundation of China(32370836);the National key Clinical Specialty Construction Project(No.2022YW030009);the GDPH Supporting Fund for Talent Program(KY012021209);the Natural Science Foundation of Guangdong Province(2023A1515110294);the NSFC Incubation Project of Guangdong Provincial People’s Hospital(KY0120220049);the Science and Technology Program of Guangzhou(2023A04J0536).

摘　　要：The precise combination of conflicting biological properties through sophisticated structural and functional design to meet all the requirements of anastomotic healing is of great demand but remains challenging.Here,we develop a smart responsive anastomotic staple(Ti–OH-MC)by integrating porous titanium anastomotic staple with multifunctional polytannic acid/tannic acid coating.This design achieves dynamic sequential regulation of antibacterial,anti-inflammatory,and cell proliferation properties.During the inflammatory phase of the anastomotic stoma,our Ti–OH-MC can release tannic acid to provide antibacterial and anti-inflammatory properties,together with immune microenvironment regulation function.At the same time,as the healing progresses,the multifunctional coating gradually falls off to expose the porous structure of the titanium anastomotic staple,which promotes cell adhesion and proliferation during the later proliferative and remodeling phases.As a result,our Ti–OH-MC exceeds the properties of clinically used titanium anastomotic staple,and can effectively promote the healing.The staple’s preparation strategy is simple and biocompatible,promising for industrialisation and clinical application.This work provides an effective anastomotic staple for anastomotic stoma healing and serve as a reference for the functional design and preparation of other types of titanium-based tissue repair materials.

关 键 词：Anastomotic staple Smart responsive Coating Tannic acid Anastomotic stoma healing 

分 类 号：TG174.4[金属学及工艺—金属表面处理]