Radiopaque FeMnN-Mo composite drawn filled tubing wires for braided absorbable neurovascular devices  

作　　者：Adam J.Griebel Petra Maier Henry Summers Benjamin Clausius Isabella Kanasty Weilue He Nicholas Peterson Carolyn Czerniak Alexander A.Oliver David F.Kallmes Ramanathan Kadirvel Jeremy E.Schaffer Roger J.GuilloryⅡ 

机构地区：[1]Fort Wayne Metals,Fort Wayne,IN,USA [2]School of Mechanical Engineering,Stralsund University of Applied Sciences,Stralsund,DE,USA [3]Department of Materials Science and Engineering,Michigan Technological University,USA [4]Department of Biomedical Engineering,Michigan Technological University,USA [5]Department of Biological Sciences,Michigan Technological University,USA [6]Joint Department of Biomedical Engineering,Medical College of Wisconsin,Marquette University,USA [7]Department of Radiology,Mayo Clinic,Rochester,MN,USA [8]Department of Neurosurgery,Mayo Clinic,Rochester,MN,USA

出　　处：《Bioactive Materials》2024年第10期74-87,共14页生物活性材料（英文）

基　　金：support of Carlo Wolf(School of Mechanical Engineering,University of Applied Sciences Stralsund)for support with the CT analysis and metallographic preparation,Aubrey L.Ehle(Indiana University School of Medicine)for support with the radiopacity assessment,and Amani Gillette(Morgridge Institute for Research)for support with the cytotoxicity analysis.Parts of this study were completed using Michigan Technological University’s Applied Chemical and Morphological Analysis Laboratory.RG and NP were partially supported by NIH R15HL167221;AO is supported by American Heart Association grant 23PRE1012781.

摘　　要：Flow diverter devices are small stents used to divert blood flow away from aneurysms in the brain,stagnating flow and inducing intra-aneurysmal thrombosis which in time will prevent aneurysm rupture.Current devices are formed from thin(~25μm)wires which will remain in place long after the aneurysm has been mitigated.As their continued presence could lead to secondary complications,an absorbable flow diverter which dissolves into the body after aneurysm occlusion is desirable.The absorbable metals investigated to date struggle to achieve the necessary combination of strength,elasticity,corrosion rate,fragmentation resistance,radiopacity,and biocompatibility.This work proposes and investigates a new composite wire concept combining absorbable iron alloy(FeMnN)shells with one or more pure molybdenum(Mo)cores.Various wire configurations are produced and drawn to 25–250μm wires.Tensile testing revealed high and tunable mechanical properties on par with existing flow diverter materials.In vitro degradation testing of 100μm wire in DMEM to 7 days indicated progressive corrosion and cracking of the FeMnN shell but not of the Mo,confirming the cathodic protection of the Mo by the FeMnN and thus mitigation of premature fragmentation risk.In vivo implantation and subsequentμCT of the same wires in mouse aortas to 6 months showed meaningful corrosion had begun in the FeMnN shell but not yet in the Mo filament cores.In total,these results indicate that these composites may offer an ideal combination of properties for absorbable flow diverters.

关 键 词：corrosion COMPOSITE FILLED 

分 类 号：TB33[一般工业技术—材料科学与工程]