Multiscale engineered artificial compact bone via bidirectional freeze-driven lamellated organization of mineralized collagen microfibrils  

作　　者：Lingwenyao Kong Yonggang Zhao Yang Xiong Junlin Chen Shuo Wang Ziming Yan Huibin Shi Zhanli Liu Xiumei Wang 

机构地区：[1]State Key Laboratory of New Ceramics and Fine Processing,Key Laboratory of Advanced Materials of Ministry of Education,School of Materials Science and Engineering,Tsinghua University,Beijing,100084,China [2]State Key Laboratory for Performance and Structure Safety of Petroleum Tubular Goods and Equipment Materials,Tubular Goods Research Institute of CNPC,Xi’an,710077,China [3]Department of Orthopedics,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,China [4]School of Aerospace Engineering,Tsinghua University,Beijing,100084,China

出　　处：《Bioactive Materials》2024年第10期168-181,共14页生物活性材料（英文）

基　　金：supported by the National Key R&D Program of China(No.2023YFC2412300 and 2020YFC1107600);the Key R&D Program in Shandong Province(No.2019JZZY011106);the Foshan-Tsinghua Industry-University-Research Cooperation Collaborative Innovation Project.

摘　　要：Bone,renowned for its elegant hierarchical structure and unique mechanical properties,serves as a constant source of inspiration for the development of synthetic materials.However,achieving accurate replication of bone features in artificial materials with remarkable structural and mechanical similarity remains a significant challenge.In this study,we employed a cascade of continuous fabrication processes,including biomimetic mineralization of collagen,bidirectional freeze-casting,and pressure-driven fusion,to successfully fabricate a macroscopic bulk material known as artificial compact bone(ACB).The ACB material closely replicates the composition,hierarchical structures,and mechanical properties of natural bone.It demonstrates a lamellated alignment of mineralized collagen(MC)microfibrils,similar to those found in natural bone.Moreover,the ACB exhibits a similar high mineral content(70.9%)and density(2.2 g/cm^(3))as natural cortical bone,leading to exceptional mechanical properties such as high stiffness,hardness,and flexural strength that are comparable to those of natural bone.Importantly,the ACB also demonstrates excellent mechanical properties in wet,outstanding biocompatibility,and osteogenic properties in vivo,rendering it suitable for a broad spectrum of biomedical applications,including orthopedic,stomatological,and craniofacial surgeries.

关 键 词：Artificial compact bone Bidirectional freeze-casting Mineralized collagen microfibril Hierarchical structures 

分 类 号：R318[医药卫生—生物医学工程]