Advanced biomedical and electronic dual-function skin patch created through microfluidic-regulated 3D bioprinting  

作　　者：Ting Dong Jie Hu Yue Dong Ziyi Yu Chang Liu Gefei Wang Su Chen 

机构地区：[1]State Key Laboratory of Materials-Oriented Chemical Engineering,College of Chemical Engineering,Jiangsu Key Laboratory of Fine Chemicals and Functional Polymer Materials,Nanjing Tech University,Nanjing,210009,China [2]Department of General Surgery,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing,210002,China

出　　处：《Bioactive Materials》2024年第10期261-274,共14页生物活性材料（英文）

基　　金：supported by National Natural Science Foundation of China(22278225,82170581,22308160);Natural Science Foundation of Jiangsu Province(BK20211133,BK20230327);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_1471);Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).

摘　　要：Artificial skin involves multidisciplinary efforts,including materials science,biology,medicine,and tissue engineering.Recent studies have aimed at creating skins that are multifunctional,intelligent,and capable of regenerating tissue.In this work,we present a specialized 3D printing ink composed of polyurethane and bioactive glass(PU-BG)and prepare dual-function skin patch by microfluidic-regulated 3D bioprinting(MRBP)technique.The MRBP endows the skin patch with a highly controlled microstructure and superior strength.Besides,an asymmetric tri-layer is further constructed,which promotes cell attachment and growth through a dual transport mechanism based on hydrogen bonds and gradient structure from hydrophilic to superhydrophilic.More importantly,by combining the features of biomedical skin with electronic skin(e-skin),we achieved a biomedical and electronic dual-function skin patch.In vivo experiments have shown that this skin patch can enhance hemostasis,resist bacterial growth,stimulate the regeneration of blood vessels,and accelerate the healing process.Meanwhile,it also mimics the sensory functions of natural skin to realize signal detection,where the sensitivity reached up to 5.87 kPa1,as well as cyclic stability(over 500 cycles),a wide detection range of 0–150 kPa,high pressure resolution of 0.1%under the pressure of 100 kPa.This work offers a versatile and effective method for creating dual-function skin patches and provide new insights into wound healing and tissue repair,which have significant implications for clinical applications.

关 键 词：3D bioprinting Skin patches Wound healing Pressure sensor 

分 类 号：R318[医药卫生—生物医学工程]