In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence  

作　　者：Wanying Li Yinghui Wang Chaojie Che Xinyu Fu Yang Liu Dongzhi Xue Shuai Zhang Rui Niu Hao Zhang Yue Cao Shuyan Song Liren Cheng Hongjie Zhang 

机构地区：[1]State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,Jilin,130022,PR China [2]School of Applied Chemistry and Engineering,University of Science and Technology of Chin1,Hefei,Anhui 230026,PR China [3]Department of Chemistry,Tsinghua University,Beijing,100084,PR China [4]The First Hospital of Jilin University,Changchun,Jilin,130022,PR China

出　　处：《Bioactive Materials》2024年第10期474-483,共10页生物活性材料（英文）

基　　金：supported by the financial aid from the Basic Science Center Project of the National Natural Science Foundation of China(22388101);National Natural Science Foundation of China(Grant Nos.22020102003,U23A20581,52272169,and 52022094);National Key R&D Program of China(2020YFA0712102);the Program of Science and Technology Development Plan of Jilin Province of China(No.20230508071RC);the Youth Innovation Promotion Association of Chinese Academy of Sciences (Grant 2019232).

摘　　要：Invasive tumors are difficult to be completely resected in clinical surgery due to the lack of clear resection margins,which greatly increases the risk of postoperative recurrence.However,chemotherapy and radiotherapy as the traditional means of postoperative adjuvant therapy,are limited in postoperative applications,such as multi-drug resistance and low sensitivity,etc.Therefore,an engineered magnesium alloy rod is designed as a postoperative implant to completely remove postoperative residual tumor tissue and inhibit tumor recurrence by gas and mild magnetic hyperthermia therapy(MMHT).As a reactive metal,magnesium alloy responds to the acidic tumor microenvironment by continuously generating hydrogen.The in-situ generation of hydrogen not only protects the surrounding normal tissue,but also enables the magnesium alloy to achieve MMHT under lowintensity alternating magnetic field(AMF).Furthermore,the numerous reactive oxygen species(ROS)produced by heat stress will combine with nitric oxide(NO)generated in situ,to produce more toxic reactive nitrogen species(RNS)storm.In summary,engineered magnesium alloy can completely remove residual tumor tissue and inhibit tumor recurrence by MMHT and RNS storm under low-intensity AMF,and the biodegradability of magnesium alloy makes great potential for clinical application.

关 键 词：Magnesium alloy Gas therapy Mild magnetic hyperthermia therapy Postsurgical tumor recurrence 

分 类 号：TG146.22[一般工业技术—材料科学与工程]