Nature-based bioreactors: Tackling antibiotic resistance in urban wastewater treatment  

作　　者：Lluís Bertrans-Tubau Sergio Martínez-Campos Julio Lopez-Doval Meritxell Abril Sergio Ponsá Victoria Salvadó Manuela Hidalgo Anna Pico-Tomàs Jose Luis Balcazar Lorenzo Proia 

机构地区：[1]BETA Technological Centre-University of Vic-Central University of Catalunya(BETA-UVIC-UCC),Carretera de Roda 70,08500,Vic,Barcelona,Spain [2]Chemistry Department,University of Girona.Campus Montilivi,17005,Girona,Spain [3]Catalan Institute Water Research(ICRA-CERCA),Emili Grahit 101,17003,Girona,Spain [4]University of Girona,17004,Girona,Spain

出　　处：《Environmental Science and Ecotechnology》2024年第6期155-167,共13页环境科学与生态技术（英文）

基　　金：Spanish Ministry of Science and Innovation(Project PID2021-127326OB-100);Spanish Ministry of Science and Innovation,the State Investigation Agency and the Regional Development of European Funding(FRENAWASTE Project:PID2022-1385630A-100);L.P has received funding from the Spanish Ministry of Science and Innovation through a Ramón y Cajal contract ‘[RYC 2020-029829-I]’;L.B.T has received funding from the European Social Funding Plus (FSE+);Generalitat de Catalunya (grant number 2022_FI_B2 00 027).

摘　　要：The overuse and misuse of antibiotics have accelerated the selection of antibiotic-resistant bacteria,significantly impacting human,animal,and environmental health.As aquatic environments are vulnerable to antibiotic resistance,suitable management practices should be adopted to tackle this phenomenon.Here we show an effective,nature-based solution for reducing antibiotic resistance from actual wastewater.We utilize a bioreactor that relies on benthic(biofilms)and planktonic microbial communities to treat secondary effluent from a small urban wastewater treatment plant(<10,000 population equivalent).This treated effluent is eventually released into the local aquatic ecosystem.We observe high removal efficiency for genes that provide resistance to commonly used antibiotic families,as well as for mobile genetic elements that could potentially aid in their spread.Importantly,we notice a buildup of sulfonamide(sul1 and sul2)and tetracycline(tet(C),tet(G),and tetR)resistance genes specifically in biofilms.This advancement marks the initial step in considering this bioreactor as a nature-based,cost-effective tertiary treatment option for small UWWTPs facing antibiotic resistance challenges.

关 键 词：ARGs MGEs UWWTPs NBS Biofilms 

分 类 号：X703[环境科学与工程—环境工程]