Gestational PFAS exposure and newborn size:The modifying effect of cord blood fatty acids  

作　　者：Chang Gao Lin Luo Yijun Fan Liyan Guo Lijuan Guo Lin Tao Fangbiao Tao De-Xiang Xu Robert A.Gibson Maria Makrides Hua Wang Yichao Huang 

机构地区：[1]Department of Toxicology,School of Public Health,Anhui Medical University,Hefei,230031,China [2]Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes,Anhui Medical University,Hefei,230031,China [3]Center for Big Data and Population Health of IHM,Anhui Medical University,Hefei,230031,China [4]MOE Key Laboratory of Population Health Across Life Cycle,Anhui Medical University,Hefei,230031,China [5]Department of Gynecology and Obstetrics,The Second Affiliated Hospital of Anhui Medical University,Hefei,230601,China [6]Department of Maternal&Child and Adolescent Health,School of Public Health,Anhui Medical University,Hefei,230031,China [7]SAHMRI Women and Kids,South Australian Health and Medical Research Institute,North Adelaide,5000,South Australia,Australia [8]Clinical Research Center,Suzhou Hospital of Anhui Medical University,Suzhou,234099,China

出　　处：《Environmental Science and Ecotechnology》2024年第6期294-303,共10页环境科学与生态技术（英文）

基　　金：National Natural Science Foundation of China(82373586 and 82173484);Anhui Provincial Natural Science Foundation(2308085Y50);Education Department of Anhui Province for Excellent Young Scientist(2022AH030076);Center for Big Data and Population Health of IHM(JKS2022020).

摘　　要：Per-and polyfluoroalkyl substances(PFASs)can disrupt lipid metabolism,and changes in cord blood fatty acid composition have been observed in small newborns.Emerging evidence suggests that exposure to PFASs during pregnancy is linked to decreased newborn size,although the evidence is not consistent.The modifying effect of fatty acids on the associations of gestational PFAS exposure with newborn size is still unknown.Here we show that the nutritional status of the fetus,as indicated by the level of fatty acids in the cord blood,mitigates the adverse effects of gestational PFAS exposure on the size of the newborn.Our study confirms the adverse developmental effects of PFASs and identifies emerging short-chain PFASs as the primary drivers of reduced newborn size,despite their lower exposure burden compared to legacy PFASs.Additionally,we find the protective role of cord blood fatty acids,suggesting potential strategies for mitigating the detrimental effects of emerging environmental exposures on human health.Our findings provide new evidence of the potential toxicity of emerging PFASs and call for further toxicity evaluations of these pollutants for regulatory purposes.Future studies should consider the complex interaction between exposure and nutrition within the human body,particularly during the first thousand days of life,to promote lifelong health.

关 键 词：Per-and polyfluoroalkyl substance Gestational exposure Fetal nutrition Fatty acid status Newborn size 

分 类 号：X592[环境科学与工程—环境工程] X503