正常低密度脂蛋白胆固醇人群残余胆固醇与颈部动脉粥样硬化斑块的关联分析  

Association between remnant cholesterol and cervical atherosclerotic plaque in normal low density lipoprotein cholesterol population

作　　者：张丽华[1] 闫肃 秦迁[1] 陈静锋 丁素英[1,3] ZHANG Lihua;YAN Su;QIN Qian;CHEN Jingfeng;DING Suying(Health Management Center,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Institute for Prevention and Control of Infectious Diseases,Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016;Henan Internet Smart Health Management Institute,Zhengzhou 450052)

机构地区：[1]郑州大学第一附属医院健康管理中心,郑州450052 [2]河南省疾病预防控制中心传染病预防控制所,郑州450016 [3]河南省互联智慧健康管理研究院,郑州450052

出　　处：《郑州大学学报（医学版）》2024年第6期846-850,共5页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210354);郑州大学第一附属医院护理团队科研项目(HLKY2023005)。

摘　　要：目的:分析残余胆固醇(RC)与正常低密度脂蛋白胆固醇人群颈部动脉粥样硬化斑块患病风险的关联。方法:选择2016年9月至2023年6月体检的正常低密度脂蛋白胆固醇者7152人,依据RC分为低、高RC组,绘制Kaplan-Meier风险曲线,并通过Log-rank检验进行比较,采用Cox比例风险模型分析颈部动脉粥样硬化斑块的危险因素,采用限制性立方样条回归分析RC与颈部动脉粥样硬化斑块发生风险的关系。结果:Cox回归分析显示年龄、性别、RC、糖化血红蛋白为颈部动脉粥样硬化斑块的影响因素,HR(95%CI)分别为1.041(1.037~1.046)、1.153(1.042~1.276)、1.123(1.023~1.233)、1.088(1.024~1.156);RC水平与颈部动脉粥样硬化斑块发生风险有关(P=0.033),随RC增高,患病风险呈先逐渐增高再平稳趋势。结论:RC升高可增加正常低密度脂蛋白胆固醇人群颈部动脉粥样硬化斑块发生风险。Aim:To investigate the association of remnant cholesterol(RC)with the risk of cervical atherosclerotic plaque in normal low density lipoprotein cholesterol population.Methods:A total of 7152 individuals who accepted physical examination from September 2016 ro June 2023 were chosen and allocated into higher and lower groups according to RC.Kaplan-Meier risk curve was drawn,and Log-rank test was used to compare the difference.Cox proportional risk model was used to explore the risk factors of cervical atherosclerotic plaque,and restricted cubic spline regression was used to analyze whether there was a dose-response relationship between RC level and the risk of cervical atherosclerotic plaque.Results:Cox regression analysis showed that age,gender,RC and glycated hemoglobin were influential risk factors of carotid plaque,and HR(95%CI)was 1.041(1.037-1.046),1.153(1.042-1.276),1.123(1.023-1.233),1.088(1.024-1.156),respectively.There was a relationship between RC level and the risk of cervical atherosclerotic plaque(P=0.033).With the increase of RC,the risk of cervical atherosclerotic plaque first increased gradually and then stabilized.Conclusion:The elevated RC could increase the risk of cervical atherosclerotic plaque in normal low density lipoprotein cholesterol population.

关 键 词：残余胆固醇 颈部动脉粥样硬化斑块 限制性立方样条 

分 类 号：R543.4[医药卫生—心血管疾病]