血清基础黄体生成素水平对多囊卵巢综合征患者卵泡期长效长方案助孕结局的影响  

Effects of serum basal luteinizing hormone on pregnancy and neonatal outcomes in patients with polycystic ovary syndrome using long-acting GnRH agonist long protocol in follicular phase

作　　者：朱瑞可 孙婧[1] 史昊 陈彩虹[1] ZHU Ruike;SUN Jing;SHI Hao;CHEN Caihong(The Reproductive Medicine Center,the First Affiliated Hospital,Zhengzhou University,Henan Key Laboratory of Reproductive and Genetic Diseases,Zhengzhou 450052)

机构地区：[1]郑州大学第一附属医院生殖医学中心,河南省生殖与遗传病重点实验室,郑州450052

出　　处：《郑州大学学报（医学版）》2024年第6期859-862,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨血清基础黄体生成素(bLH)水平对多囊卵巢综合征(PCOS)患者卵泡期长效长方案助孕结局的影响。方法:回顾性分析2018年3月至2021年7月于郑州大学第一附属医院生殖医学中心首次行体外受精/卵泡浆内单精子注射-胚胎移植助孕治疗并采用卵泡期长效长方案的4926例PCOS患者的临床资料。根据进周期前血清bLH水平将患者分为3组:A1组(bLH<10 U/L,n=4088)、A2组(bLH 10~<20 U/L,n=709)、A3组(bLH≥20 U/L,n=129),比较3组患者的一般特征、促排卵情况、妊娠结局以及新生儿结局等相关指标。结果:A2、A3组卵巢高反应全胚冷冻率高于A1组;3组妊娠结局指标如生化妊娠率、临床妊娠率、早期流产率、晚期流产率及活产率差异均无统计学意义(P>0.05);新生儿结局指标如新生儿出生体重、早产率、过期产率、低出生体重儿比例及巨大儿率差异均无统计学意义(P>0.05)。结论:血清bLH水平对PCOS患者卵泡期长效长方案助孕结局无不良影响。Aim:To explore the effects of serum basal luteinizing hormone(bLH)level on pregnancy and neonatal outcomes in infertile patients with polycystic ovarian syndrome(PCOS)using long-acting GnRH agonist(GnRH-a)long protocol in follicular phase.Methods:To retrospectively analyze the clinical data of 4926 infertile women with PCOS undergoing their first in vitro fertilization/intracytoplasmic sperm injection-embryo transfer and ovarian stimulation cycle by using long-acting GnRH-a long protocol between March 2018 and July 2021 in the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University.According to serum bLH level,the PCOS patients were allocated into 3 groups,group A1(bLH<10 U/L,n=4088),group A2(bLH 10-<20 U/L,n=709),and group A3(bLH≥20 U/L,n=129).The general characteristics,ovulation induction characteristics,pregnancy outcomes and neonatal outcomes were compared among the 3 groups.Results:Ovary high response whole embryo freezing rate was higher in A1,A3 groups,however there were no significant differences in pregnancy outcomes among the 3 groups,including biochemical pregnancy rate,clinical pregnancy rate,early abortion rate,advanced abortion rate and live birth rate(P>0.05).There were no significant differences in neonatal birth weight,premature birth rate,post-term birth rate,or rates of low birth weight infants and macrosomia among the 3 groups(P>0.05).Conclusion:Serum bLH level does not affect pregnancy or neonatal outcomes in infertile patients with PCOS using long-acting GnRH-a long protocol in follicular phase.

关 键 词：基础黄体生成素 多囊卵巢综合征 卵泡期长效长方案 辅助生殖 

分 类 号：R711.6[医药卫生—妇产科学]