骨碱性磷酸酶活性联合骨密度检测早期诊断小儿佝偻病的临床价值  

Clinical Value of Combined Detection of Bone Alkaline Phosphatase Activity and Bone Mineral Density in Early Diagnosis of Rickets in Children

作　　者：袁云鹰 刘安 YUAN Yunying;LIU An(Department of Clinical Laboratory,Xingguo County Maternal and Child Health Hospital,Xingguo 342400,Jiangxi,China)

机构地区：[1]兴国县妇幼保健院检验科,江西兴国342400

出　　处：《医学信息》2024年第22期146-148,156,共4页Journal of Medical Information

基　　金：赣州市指导性科技计划项目(编号:GZ2023ZSF678)。

摘　　要：目的探讨骨碱性磷酸酶(BALP)活性联合骨密度检测早期诊断小儿佝偻病的临床价值。方法选取2022年1月-2023年12月兴国县妇幼保健院收治的72例佝偻病婴幼儿作为观察组,并将其分为初期、活动期、恢复期、后遗症期,另选取同期我院体检的72名健康婴幼儿作为对照组。比较两组及观察组不同分期患儿BALP及骨密度水平,分析BALP联合骨密度对小儿佝偻病的诊断效能,包括诊断敏感性、特异性、准确性、漏诊率和误诊率。结果观察组BALP水平高于对照组,骨密度低于对照组(P<0.05)。观察组活动期、恢复期、后遗症期患儿的BALP水平均高于初期患儿,且活动期、恢复期、后遗症期患儿的骨密度水平均低于初期患儿(P<0.05)。BALP联合骨密度诊断小儿佝偻病的敏感性、特异性、准确性高于BALP、骨密度单独检测,且两者联合检测的漏诊率和误诊率低于单独检测(P<0.05)。结论BALP及骨密度水平与小儿佝偻病具有密切联系,对小儿佝偻病早期诊断具有重要价值,且两者联合检测可进一步提升诊断准确率。Objective To investigate the clinical value of bone alkaline phosphatase(BALP)activity combined with bone mineral density in early diagnosis of rickets in children.Methods A total of 72 infants with rickets admitted to Xingguo County Maternal and Child Health Hospital from January 2022 to December 2023 were selected as the observation group,and they were divided into the initial stage,active stage,recovery stage and sequelae stage.In addition,72 healthy infants who underwent physical examination in our hospital during the same period were selected as the control group.The levels of BALP and bone mineral density were compared between the two groups and the observation group at different stages.The diagnostic efficacy of BALP combined with bone mineral density in children with rickets was analyzed,including diagnostic sensitivity,specificity,accuracy,missed diagnosis rate and misdiagnosis rate.Results The BALP level of the observation group was higher than that of the control group,and the bone mineral density was lower than that of the control group(P<0.05).In the observation group,the BALP levels of children in the active stage,recovery stage and sequelae stage were higher than those in the initial stage,and the bone mineral density levels of children in the active stage,recovery stage and sequelae stage were lower than those in the initial stage(P<0.05).The sensitivity,specificity and accuracy of BALP combined with bone mineral density in the diagnosis of rickets in children were higher than those of BALP and bone mineral density alone,and the missed diagnosis rate and misdiagnosis rate of combined detection were lower than those of single detection(P<0.05).Conclusion The levels of BALP and bone mineral density are closely related to rickets in children,which are of great value in the early diagnosis of rickets in children,and the combined detection of the two can further improve the diagnostic accuracy.

关 键 词：骨碱性磷酸酶活性 骨密度 小儿佝偻病 

分 类 号：R722.1[医药卫生—儿科]