社区老年人群肌少症的临床特点及其与高血压的相关性  

Clinical characteristics of sarcopenia and its correlation with hypertension in community-dwelling elderly

作　　者：何浩 肖芳萍 鲁翔 徐金水[4] 沈征锴 高伟 洪梅[1] He Hao;Xiao Fangping;Lu Xiang;Xu Jinshui;Shen Zhengkai;Gao Wei;Hong Mei(Department of Cardiology,Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China;Department of Cardiology,Haian People′s Hospital Affiliated to Nantong University,Nantong 226600,Jiangsu Province,China;Department of Geriatrics,Sir Run Run Hospital of Nanjing Medical University,Nanjing 211100,China;Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China)

机构地区：[1]南京医科大学第二附属医院心血管内科,南京210011 [2]南通大学附属海安人民医院心血管内科,江苏南通226600 [3]南京医科大学附属逸夫医院老年医学科,南京211100 [4]江苏省疾病预防控制中心,南京210009

出　　处：《中华老年多器官疾病杂志》2024年第11期836-841,共6页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家重点公共卫生项目(2020YFC2008505)。

摘　　要：目的调查南京地区城市老年人群肌少症患病率、相关危险因素及临床特点,探讨肌少症与高血压的相关性。方法选取2020年1月至12月于南京市迈皋桥社区医疗中心参与年度体检的2536名老年人为研究对象,调查基本特征、生活方式、基础疾病史以及实验室指标。根据是否符合肌少症诊断标准,将患者分为肌少症组198例及对照组2338名。采用SPSS 24.0统计软件进行数据分析。根据数据类型,组间比较分别采用t检验、Z检验或χ^(2)检验。采用logistic回归分析评估肌少症的影响因素。结果南京地区城市老年人群中肌少症的患病率为7.8%(198/2536),且肌少症的患病率随年龄增长而增加,随血压升高而增加,差异均有统计学意义(均P<0.05)。高血压(OR=3.075,95%CI 2.077~4.551;P<0.001)与肌酐升高(OR=1.010,95%CI 1.003~1.016;P=0.005)是肌少症的独立危险因素,而低体质量指数(BMI;OR=0.676,95%CI 0.632~0.723;P<0.001)、乳类摄入(OR=0.532,95%CI 0.379~0.748;P<0.001)、锻炼(OR=0.216,95%CI 0.150~0.312;P<0.001)是肌少症的独立保护因素。高血压人群中肌少症患病率为9.1%(151/1656)。高龄(OR=1.156,95%CI 1.119~1.194;P<0.001)、尿素氮升高(OR=1.177,95%CI 1.045~1.324;P=0.007)和血红蛋白升高(OR=1.026,95%CI 1.010~1.043;P=0.001)是高血压人群肌少症的独立危险因素,而低BMI(OR=0.613,95%CI 0.559~0.673;P<0.001)、乳类摄入(OR=0.499,95%CI 0.320~0.778;P=0.002)与锻炼(OR=0.148,95%CI 0.093~0.235;P<0.001)是高血压人群肌少症的独立保护因素。结论肌少症患病率随血压升高而增长,高血压是肌少症发生的独立危险因素,临床应多加关注老年高血压患者的肌少症问题。Objective To investigate the prevalence,related risk factors,and clinical characteristics of sarcopenia in elderly urban populations in Nanjing,and explore the correlation between sarcopenia and hypertension.Methods A total of 2536 elderly people who participated in annual physical examinations in Maigaoqiao Community Medical Center in Nanjing from January to December 2020 were recruited in this study.Their basic characteristics,life style,history of underlying diseases,and laboratory examination were surveyed and collected.According to whether they meet the diagnostic criteria for sarcopenia,the participants were divided into a sarcopenia group(198 cases)and a control group(2338 cases).SPSS statistics 24.0 was used for data analysis.Depending on data type,student′s t test,Z test or Chi-square test was employed for intergroup comparison.Logistic regression analysis was applied to identify the influencing factors for sarcopenia.Results The prevalence of sarcopenia was 7.8%(198/2536)in the participants,and the prevalence was increased with aging and with increment of blood pressure with statistical significances(all P<0.05).Hypertension(OR=3.075,95%CI 2.077-4.551;P<0.001)and elevated creatinine(OR=1.010,95%CI 1.003-1.016;P=0.005)were independent risk factors for sarcopenia,while low body mass index(BMI)(OR=0.676,95%CI 0.632-0.723;P<0.001),dairy intake(OR=0.532,95%CI 0.379-0.748;P<0.001)and exercise(OR=0.216,95%CI 0.150-0.312;P<0.001)were independent protective factors for sarcopenia.The prevalence of sarcopenia in hypertensive participants was 9.1%(151/1656).Advanced age(OR=1.156,95%CI 1.119-1.194;P<0.001),elevated urea nitrogen(OR=1.177,95%CI 1.045-1.324;P=0.007),and increased hemoglobin(OR=1.026,95%CI 1.010-1.043;P=0.001)were independent risk factors for sarcopenia in the hypertensive population,while low BMI(OR=0.613,95%CI 0.559-0.673;P<0.001),dairy intake(OR=0.499,95%CI 0.320-0.778;P=0.002),and exercise(OR=0.148,95%CI 0.093-0.235;P<0.001)were independent protective factors for sarcopenia in the hypertensive p

关 键 词：老年人 肌少症 高血压 城市居民 南京 

分 类 号：R592[医药卫生—老年医学]