干细胞移植治疗在新生儿缺氧缺血性脑病中的研究进展  

Research progress of stem cell transplantation in neonatal hypoxic-ischemic encephalopathy

作　　者：何宜峰 胡莹莹 林振浪[2] HE Yifeng;HU Yingying;LIN Zhenlang(The Second Clinical College of Medicine,Wenzhou Medical University,Wenzhou 325035,China;Department of neonatology,the Second Affiliated Hospital&Yuying Children’s Hospital of Wenzhon Medical University,Wenzhou 325027,China)

机构地区：[1]温州医科大学第二临床医学院,浙江温州325035 [2]温州医科大学附属第二医院育英儿童医院新生儿科,浙江温州325027

出　　处：《温州医科大学学报》2024年第11期942-946,F0003,共6页Journal of Wenzhou Medical University

摘　　要：新生儿缺氧缺血性脑病(HIE)是新生儿死亡的重要原因之一,其发病机制与围产期窒息密切相关。近年来,干细胞移植除了在成人及儿童心血管系统疾病、神经系统疾病等疾病中的应用日益广泛,其在新生儿HIE中也有大量研究。笔者就干细胞移植在新生儿HIE治疗中的可能作用机制及研究进展进行综述。Neonatal hypoxic-ischemic encephalopathy(HIE)is one of the most important causes of neonatal death,and its pathogenesis is closely related to perinatal asphyxia.In recent years,stem cell transplantation has been widely used in cardiovascular and neurological diseases in adults and children,and it has been extensively studied in animal models of neonatal HIE.This article reviews the possible mechanism and research progress of stem cell transplantation in the treatment of neonatal HIE.

关 键 词：新生儿缺氧缺血性脑病 干细胞治疗 神经血管发生 再生 

分 类 号：R722.1[医药卫生—儿科]