Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics  

作　　者：Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi Yin Ming Yang Xuxu Chen Xinhua Yin Yunlei Zhou 

机构地区：[1]Honghui Hospital,Xi’an Jiaotong University,Xi’an 710018,People’s Republic of China [2]Department of Bioengineering,Henry Samueli School of Engineering and Applied Science,University of California Los Angeles,Los Angeles 90095,USA [3]Hangzhou Institute of Technology,Xidian University,Hangzhou 311231,People’s Republic of China

出　　处：《Nano-Micro Letters》2025年第2期463-497,共35页纳微快报（英文版）

基　　金：support of the National Natural Science Foundation of China(Grant No.52205593);Shaanxi Natural Science Foundation Project(2024JC-YBMS-711).

摘　　要：The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing capability.Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and regeneration.Inspired by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone regeneration.With ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone tissue.In this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and tissue.Next,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue engineering.Finally,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关 键 词：Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue 

分 类 号：R318.08[医药卫生—生物医学工程]