奶牛酮病代谢物变化、候选基因及相关代谢途径  

Metabolite Changes,Candidate Genes and Related Metabolic Pathways of Ketosis in Dairy Cows

作　　者：曹佩佩 马敏 户春丽 马燕芬 CAO Peipei;MA Min;HU Chunli;MA Yanfen(School of Animal Science and Technology,Ningxia University,Yinchuan 750021,China)

机构地区：[1]宁夏大学动物科技学院,银川750021

出　　处：《动物营养学报》2024年第11期6864-6871,共8页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：宁夏自然科学基金项目(2023AAC03042);宁夏反刍动物营养科技创新团队(2024CXTD008);宁夏留学回国人员创新创业项目(2023)。

摘　　要：酮病作为常见的代谢性疾病,会降低奶牛产奶量和繁殖性能,增加其他围产期疾病的患病风险,对乳制品行业造成重大经济损失。酮体是奶牛酮病的重要代谢信号传导介质,酮病的发生涉及脂质代谢、氨基酸代谢、糖代谢等多种代谢途径和基因组改变,但对酮病奶牛体内代谢物含量变化与候选基因之间的相关性缺乏了解。本文综述了酮体对奶牛机体内代谢的改变,并筛选酮病靶向基因,结合候选基因与代谢途径分析,有助于阐明奶牛酮病发病的潜在分子机制,为生产实践中快速精准诊断奶牛酮病提供技术支撑。Ketosis as a common metabolic disease can reduce the milk yield and reproductive performance of dairy cows,increase the risk of other perinatal diseases,and cause significant economic losses to the dairy industry.Ketone body is an important metabolic signaling mediator of ketone sickness in dairy cows.The occurrence of ketosis involves many metabolic pathways and genomic changes,including lipid metabolism,amino acid metabolism and sugar metabolism,but the correlation between metabolite content changes and candidate genes in ketosis cows is lacking.This review summarizes the changes of ketone body metabolism in dairy cows,and the screening of ketosis targeted genes,combining candidate genes and metabolic pathway analysis can help to elucidate the potential molecular mechanism of ketosis in dairy cows,and provide technical support for the rapid and accurate diagnosis of ketosis in dairy cows in production practice.

关 键 词：奶牛 酮病 代谢机制 候选基因 

分 类 号：S823[农业科学—畜牧学]