壳寡糖对肠道黏膜屏障功能保护作用的研究进展  

Research Progress on Protective Effects of Chitosan Oligosaccharides on Intestinal Mucosal Barrier Function

作　　者：王浩轩 张迦 兰瑞霞 WANG Haoxuan;ZHANG Jia;LAN Ruixia(College of Coastal Agricultural Sciences,Guangdong Ocean University,Zhanjiang 524088,China)

机构地区：[1]广东海洋大学滨海农业学院,湛江524088

出　　处：《动物营养学报》2024年第11期6917-6928,共12页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：广东海洋大学科研启动项目(R18005)。

摘　　要：壳寡糖是自然界唯一大量存在的碱性氨基寡糖,具有抗氧化、抗炎和抗菌等生物学功能,可作为动物饲粮中安全有效的饲料添加剂。目前,对壳寡糖的研究主要集中在畜禽的生长性能、抗氧化和免疫功能等方面。近几年研究表明,壳寡糖对肠道损伤也有保护作用,因此受到广泛关注。本文综述了壳寡糖的生物学功能及对肠道黏膜屏障损伤的保护作用,旨在为壳寡糖在畜禽生产中的应用提供参考依据。Chitosan oligosaccharides are the only alkaline amino oligosaccharides that exist in large quantity in nature.Chitosan oligosaccharides have antioxidant,anti-inflammatory,antibacterial and other biological functions,and can be used as safe and effective feed additives in animal diets.At present,the research on chitosan oligosaccharides mainly focuses on the growth performance,antioxidant and immune function in livestock and poultry.In recent years,studies have shown that chitosan oligosaccharides also have protective effects on intestinal damage,so they have been widely concerned.This article reviewed the biological functions of chitosan oligosaccharides and their protective effects on intestinal mucosal barrier function,aiming to provide theoretical references for the application of chitosan oligosaccharides in livestock and poultry production.

关 键 词：壳寡糖 肠道屏障功能 紧密连接蛋白 

分 类 号：S816[农业科学—饲料科学]