基于中西医临床病证特点的糖尿病视网膜病变动物模型分析  

Animal Models of Diabetic Retinopathy Based on Characteristics of Clinical Symptoms of Traditional Chinese and Western Medicine

作　　者：葛君玺 谢逸轩 康乐 苗明三[1] 白明[1] GE Junxi;XIE Yi xuan;KANG Le;MIAO Mingsan;BAI Ming(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学药学院,郑州450046

出　　处：《中药药理与临床》2024年第10期80-84,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家中医药管理局标准化项目(编号:GZY-FJS-2020-219);河南省重大公益专项(编号:201300310100);河南省中医药科学研究专项课题(编号:20-21ZYZD02)。

摘　　要：糖尿病视网膜病变(Diabetic Retinopathy,DR)是糖尿病并发症之一,严重危害患者的视力。本文基于糖尿病视网膜病变的中西医临床病证特点,对现常用糖尿病视网膜病变动物模型进行分析总结,分析动物模型的优缺点及未来应用方向。结果发现目前存在的糖尿病视网膜病变模型的构建方法有诱导法和自发基因型,其中链脲佐菌素(STZ)诱导法和高糖高脂饮食联合STZ诱导法最常用;而自发基因型中由于啮齿类动物成本较高,国内研究较少,斑马鱼自发基因型缺乏统一的中医评价标准等,限制了糖尿病视网膜病变动物模型的发展,因此建立一种更符合人类糖尿病视网膜病变发展过程的动物模型是发展所需,也对本病防治、发病机制的阐述及新药的开发有重大意义。Diabetic retinopathy(DR)is one of the complications of diabetes mellitus,which seriously endangers the vision of patients.Based on the clinical symptoms of DR in traditional Chinese and western medicine,this paper analyzed and summarized the commonly used animal models of DR,and analyzed the advantages and disadvantages of animal models and the future application directions.The Results showed that the existing methods for inducing models of DR included induction method and spontaneous genotype,among which streptozotocin(STZ)induction method and high-sugar and high-fat diet combined with STZ induction method were the most commonly used.The spontaneous genotype was less studied in China due to the high cost of rodents.The small number of studies on the spontaneous genotype,the lack of unified traditional Chinese medicine(TCM)evaluation criteria for zebrafish,and other factors limited the development of animal models of DR.Therefore,it is necessary to establish an animal model that is more in line with the development process of DR in human,which is also of great significance for the prevention and treatment of the disease,the elaboration of the pathogenesis,and the development of new drugs.

关 键 词：糖尿病视网膜病变 动物模型 中西医临床病证 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学] R-332[医药卫生—临床医学]