基于“肾主骨生髓”理论探讨淫羊藿治疗阿尔兹海默病的研究进展  

Research Progress in the Treatment of Alzheimer's Disease with Yinyanghuo(淫羊藿)Based on the Theory of Shenzhugushengsui(肾主骨生髓)

作　　者：龙静 黄南渠 罗勇 LONG Jing;HUANG Nanqu;LUO Yong(Department of Neurology,The Third Affiliated Hospital of Zunyi Medical University(The First People's Hospital of Zunyi),Zunyi 563000)

机构地区：[1]遵义医科大学第三附属医院(遵义市第一人民医院),神经内科,遵义563000

出　　处：《中药药理与临床》2024年第10期90-95,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金(编号:81860710);遵义市科技局课题[遵市科合社字(2018)160号]。

摘　　要：阿尔茨海默病(AD)与骨质疏松(OP)虽然临床表现不同,但根据中医理论,存在类似的病因。AD是常见的神经系统退行性疾病,也是痴呆症最常见的类型,OP是促进AD发生的风险因素之一。《黄帝内经》记载:“肾主骨,生髓,通于脑”。故髓、骨与脑有着极为密切的关系。基于此中医药理论开发治疗药物成为近年来的研究热点。淫羊藿是我国传统补益类中药之一,其代谢物淫羊藿苷、淫羊藿素和淫羊藿次苷Ⅱ现研究较多。近年来发现OP和AD存在相关性,作为补肾阳类主要集中于治疗OP,也用于研究治疗AD,目前AD和OP在临床上无法逆转病情,只能延缓其进展,本文对淫羊藿及其有效成分治疗AD和OP作一综述,为类似补肾阳类中药治疗AD和OP奠定理论基础。Although Alzheimer's disease(AD)and osteoporosis(OP)have different clinical manifestations,they have similar causes according to the traditional Chinese medicine theory.AD is a common neurodegenerative disease and the most common type of dementia.OP is one of the risk factors promoting the occurrence of AD.The Huang Di Nei Jing records:“Shenzhugu(肾主骨),Shengsui(生髓),and Tongyunao(通于脑).”Therefore,there is a close relationship between marrow,bone,and brain.Developing therapeutic drugs based on this theory has become a research hotspot in recent years.Yinyanghuo(淫羊藿)is one of tonic Chinese medicines,and its metabolites icariin,icaritin,and icariside II have been extensively studied.Studies have discovered a correlation between OP and AD.As a Shenyang(肾阳)-tonifying Chinese medicine,it is mainly used to treat not only OP but also AD.The available therapies can only delay the progression of AD and OP but not cure the diseases.This article reviews the treatment of AD and OP by Yinyanghuo and its active ingredients,laying a theoretical foundation for treating the two diseases by similar Shenyang-tonifying Chinese medicines.

关 键 词：淫羊藿 淫羊藿苷 淫羊藿素 阿尔兹海默病 骨质疏松 

分 类 号：R277.7[医药卫生—中医学]