早产儿甲状腺功能亢进1例  

A Case of Premature Infant with Hyperthyroidism

作　　者：唐文芳 朱琳 王靓 徐彦磊[3] 刘伟[1] TANG Wenfang;ZHU Lin;WANG Jing;XU Yanlei;LIU Wei(Department of Neonatology,Tongji Hospital,Tongji Medical College,Huazhong Univisity of Science and Technology,Wuhan 430030,China;Department of Neonatology,Hanyang Hospital,Wuhan 430050,China;Department of Neonatology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]华中科技大学同济医学院附属同济医院新生儿科,武汉430030 [2]武汉市汉阳医院新生儿科,武汉430050 [3]郑州大学第一附属医院新生儿科,郑州450052

出　　处：《医药导报》2024年第12期1987-1990,共4页Herald of Medicine

摘　　要：目的通过报道1例伴有甲状腺功能亢进(甲亢)的早产儿,提高临床医师对临床较少见的新生儿甲亢诊断及治疗的认识。方法回顾性分析华中科技大学同济医学院附属同济医院新生儿科诊治的1例新生儿甲亢患儿的临床资料及治疗过程,并进行相关文献复习。结果女性患儿,胎龄32周+6 d,出生即出现呼吸困难、心率加快、肝脾肿大、血小板减少、胆汁淤积、肝功能异常并持续恶化,后经甲状腺功能及抗体检测确诊为新生儿甲亢,给予甲巯咪唑,普萘洛尔及其他对症支持治疗后,患儿症状改善并痊愈出院。结论新生儿甲亢临床表现无特异性,症状不典型,故当出现生长发育迟缓、心动过速、心功能不全、呼吸急促、血小板减少、肝损伤、肝脾肿大、头围偏小等类似症状时,需要考虑到先天性甲亢的可能性,及时行甲状腺功能及抗体检查予以确诊,并早期给予相应药物干预,改善预后。Objective To improve clinicians’understanding of the diagnosis and treatment of neonatal hyperthyroidism which is rare in clinical practice.Methods The clinical data of a neonatal hyperthyroidism case diagnosed and treated was retrospectively analyzed,and the relevant literature was reviewed.Results A female infant,borned at 32 weeks and 6 days of gestation,exhibited dyspnea,a rapid heart rate,hepatosplenomegaly,thrombocytopenia,cholestasis,and abnormal liver function that continued to deteriorate after birth.She was later diagnosed with neonatal hyperthyroidism after undergoing thyroid function and antibody tests.After treated with methimazole,propranolol and other symptomatic supportive therapies,the infant’s symptoms improved and she was discharged in good health.Conclusions The clinical manifestations of neonatal hyperthyroidism are non-specific and the symptoms are atypical.Therefore,when encountering symptoms such as growth retardation,tachycardia,cardiac insufficiency,tachypnea,thrombocytopenia,liver injury,hepatosplenomegaly,and a small head circumference,it is essential to consider the possibility of congenital hyperthyroidism.Timely thyroid function and antibody tests should be conducted to confirm the diagnosis,followed by early drug intervention to enhance the prognosis.

关 键 词：早产 新生儿 甲状腺功能亢进症 诊断治疗 

分 类 号：R722[医药卫生—儿科]