中医药靶向调控miRNA干预椎间盘退变的研究进展  

Research Progress of Chinese Medicine Targeting and Regulating miRNA to Intervene Intervertebral Disc Degeneration

作　　者：汪一得 刘伟[1] 冯晶 WANG Yide;LIU Wei;FENG Jing(Hubei University of Chinese Medicine,Wuhan Hubei China 430061)

机构地区：[1]湖北中医药大学,湖北武汉430061

出　　处：《中医学报》2024年第12期2500-2508,共9页Acta Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(82104899);武汉市知识创新专项项目(2022020801020531);武汉市卫生健康委员会科研项目(WZ21C04)。

摘　　要：椎间盘退变(intervertebral disc degeneration,IDD)是很多脊柱肌肉骨骼疾病的病理基础,并且在世界范围内被公认为是主要致残原因之一。作为一种多因素病理过程,椎间盘退变相关病理改变的主要特征是细胞外基质(extracellular matrix,ECM)降解、细胞凋亡以及炎症等。微小RNA(micro RNA,miRNA)已被证实参与了几乎所有细胞过程的调控,在不同组织、不同发育阶段中的miRNA水平有显著差异,异常表达的miRNA可作为IDD早期诊断的生物标志物或者潜在的治疗靶点。部分中药复方如独活寄生汤、补肾活血方、补肾壮督方等,以及中药单体成分如牛蒡子苷元、槲皮素、桃叶珊瑚苷等可通过激活转录后调控miRNA,与miRNA部分或完全结合后调控靶基因的表达。Intervertebral disc degeneration(IDD)is the pathological basis of many spinal musculoskeletal diseases and is recognized as one of the major causes of disability worldwide.As a multifactorial pathological process,the main features of pathological changes associated with intervertebral disc degeneration are extracellular matrix(ECM)degradation,apoptosis,and inflammation.Micro RNA(miRNA)has been shown to be involved in the regulation of almost all cellular processes,with significant differences in miRNA levels in different tissues and developmental stages.Abnormally expressed miRNAs can be used as biomarkers for the early diagnosis of IDD or as potential therapeutic targets.Some traditional Chinese medicine compound formulas,such as Duhuo Jisheng Decoction,Bushen Huoxue Formula,Tonifying Kidney and Bushen Zhuangdu Formula,as well as single components of traditional Chinese medicine,such as arctigenin,quercetin,peach leaf coral glycosides,can regulate the expression of target genes by activating post-transcriptional regulator miRNAs,which are partially or completely bound to miRNAs.

关 键 词：椎间盘退变 miRNA 独活寄生汤 牛蒡子苷元 槲皮素 

分 类 号：R274.9[医药卫生—中西医结合]