中医药调节外泌体miRNA干预骨代谢疾病的研究进展  

Research Progress of Chinese Medicine Regulating Exosomal miRNA Intervention in Bone Metabolic Diseases

作　　者：张智辉 童伍岳 叶国庆 曹玉举 ZHANG Zhihui;TONG Wuyue;YE Guoqing;CAO Yuju(College of Orthopedics and Traumatology,Henan University of Chinese Medicine,Zhengzhou Henan China 450002;Zhengzhou Traditional Chinese Medicine Orthopedic Hospital Affiliated to Henan University of Chinese Medicine,Zhengzhou Henan China 450000)

机构地区：[1]河南中医药大学骨伤学院,河南郑州450002 [2]河南中医药大学附属郑州中医骨伤病医院,河南郑州450000

出　　处：《中医学报》2024年第12期2509-2516,共8页Acta Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(2023ZY2164,2024ZY2168)。

摘　　要：骨代谢疾病严重影响人类健康。近年来研究发现,外泌体作为一种重要的细胞间通信媒介,在多种生理和病理过程中发挥着巨大的作用。尤其在骨代谢的调节中,外泌体发挥着关键作用。外泌体携带的多种生物活性物质,如特定的蛋白质、脂质和核酸等,能够影响骨细胞的增殖、分化与凋亡。当前研究不仅深入探讨了外泌体miRNA在骨代谢疾病发生发展中的作用机制,还探索了其作为诊断标志物和治疗靶点的潜在应用。中医药在骨代谢疾病的治疗中具有独特优势,能够通过调控外泌体miRNA的分泌发挥治疗作用,在骨质疏松症、骨折、骨关节疾病、骨肿瘤以及骨代谢紊乱等多种骨代谢疾病的治疗中疗效显著。Bone metabolic diseases seriously affect human health.In recent years,it has been found that exosomes,as an important medium of intercellular communication,play a great role in a variety of physiological and pathological processes.Especially in the regulation of bone metabolism,exosomes play a key role.Exosomes carry a variety of biologically active substances,such as specific proteins,lipids and nucleic acids,which can affect the proliferation,differentiation and apoptosis of bone cells.The current study not only deeply explores the mechanism of exosomal miRNAs in the development of bone metabolic diseases,but also explores their potential applications as diagnostic markers and therapeutic targets.Traditional Chinese medicine has a unique advantage in the treatment of bone metabolic diseases,which can play a therapeutic role by regulating the secretion and function of exosomal miRNAs and has remarkable efficacy in treatment of various bone metabolic diseases,such as osteoporosis,bone fracture,bone and joint diseases,bone tumor,and bone metabolic disorders.

关 键 词：骨代谢疾病 外泌体miRNA 中医药 

分 类 号：R274.9[医药卫生—中西医结合]