疮愈安对热毒炽盛型低位肛周脓肿术后创面愈合的影响  

Effect of Chuangyu′an Formula on Postoperative Wound Healing of Low Perianal Abscesses with Heat and Toxin Syndrome

作　　者：刘晓博[1] 屈海涛[1] 韩海涛[1] 李阳 张东岳[1] LIU Xiaobo;QU Haitao;HAN Haitao;LI Yang;ZHANG Dongyue(The First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中医学报》2024年第12期2685-2690,共6页Acta Chinese Medicine

基　　金：河南省科技攻关项目(182102310289);河南省首批青苗人才培养项目{豫中医科教〔2018〕16号}。

摘　　要：目的:观察张东岳教授自拟方疮愈安对热毒炽盛型低位肛周脓肿术后创面愈合的影响。方法:60例热毒炽盛型低位肛周脓肿术后患者按照随机数字表法分为治疗组和对照组各30例。两组患者术后均给予抗感染治疗及常规换药,治疗组在此基础上每日口服疮愈安方。两组均以7 d为1个疗程,连续治疗两个疗程。比较两组患者术后1 d、3 d、7 d、14 d的创面疼痛程度、肉芽组织生长、创面分泌物情况、创面水肿情况、分泌物pH值、创面愈合率、创面愈合时间以及临床疗效。结果:(1)治疗组有效率为100%,对照组有效率为93.3%,两组有效率比较,差异有统计学意义(P<0.05)。(2)治疗组术后7 d、14 d的创面疼痛程度评分分别为(0.93±0.69)分、(0.37±0.56)分,肉芽组织生长评分分别为(0.43±0.63)分、(0.27±0.52)分,创面分泌物评分分别为(1.33±0.61)分、(0.63±0.67)分,均低于同期对照组,差异均有统计学意义(P<0.05)。(3)治疗组术后3 d、7 d、14 d的创面水肿评分分别为(1.70±1.06)分、(1.00±0.74)分、(0.33±0.05)分,创面分泌物pH值分别为7.83±0.27、7.69±0.31、7.28±0.22,均低于同期对照组,差异均有统计学意义(P<0.05)。(4)治疗组创面愈合时间为(29.60±3.39)d,短于对照组(P<0.05)。(5)治疗组术后7 d、14 d创面愈合面积比率分别为(26.44±7.69)%、(57.93±10.40)%,均高于同期对照组,差异均有统计学意义(P<0.05)。结论:疮愈安可有效促进热毒炽盛型低位肛周脓肿术后患者创面愈合,并有效缓解患者术后疼痛,促进肉芽组织生长,减少创面分泌物及水肿的发生,调节创面pH值以利于创面生长。Objective:To observe the effect of Chuangyu′an Formula,which was proposed by Prof.Zhang Dongyue,on postoperative wound healing of low perianal abscess with Heat and Toxin syndrome.Methods:Sixty cases of operated patients with low perianal abscess with Heat and Toxin syndrome were divided into treatment group and the control group,with 30 cases in each group,according to the method of randomized numerical table.Both groups were given anti-infection treatment and routine dressing change after surgery,and the treatment group was also treated with Chuangyu′an Formula daily in addition to that.For both groups,7d are one course of treatment,and there are two consecutive courses of treatment.Compare the degree of wound pain,granulation tissue growth,wound secretion,wound edema,secretion pH,wound healing rate,wound healing time and clinical efficacy of the two groups in 1 d,3 d,7 d and 14 d after surgery.Results:(1)The effective rate of the treatment group was 100%,and the effective rate of the control group was 93.3%,and the difference between the two groups′effective rates was statistically significant(P<0.05).(2)The traumatic pain scores of the treatment group were(0.93±0.69)and(0.37±0.56)points,the granulation tissue growth scores were(0.43±0.63)and(0.27±0.52)points,and the traumatic secretion scores were(1.33±0.61)and(0.63±0.67)points in the treatment group in the postoperative period,which were lower than those of the control group,and the differences were statistically significant(P<0.05).(3)The traumatic edema scores of the treatment group were(1.70±1.06),(1.00±0.74)and(0.33±0.05)respectively in the 3 d,7d,and 14 d postoperative periods,and the pH values of traumatic secretions were 7.83±0.27,7.69±0.31 and 7.28±0.22,respectively,which were lower than those of the control group during the same period,and the differences were statistically significant(P<0.05).(4)The wound healing time of the treatment group was(29.60±3.39)d,which was significantly shorter than that of the control group(P<0.05).(5

关 键 词：低位肛周脓肿术 热毒炽盛证 疮愈安 创面愈合 

分 类 号：R259.748[医药卫生—中西医结合]