复方延胡索乙素止痛凝胶成型性工艺优化研究  

Research on Optimization of Molding Process of Compound Tetrahydropalmatine Pain Relief Gel

作　　者：王建芬 赵一纯 姚宇 舒尊哲 WANG Jianfen;ZHAO Yichun;YAO Yu;SHU Zunzhe(Hunan Chemical Vocational Technology College,Zhuzhou 412000,China)

机构地区：[1]湖南化工职业技术学院,湖南株洲412000

出　　处：《生物化工》2024年第5期101-104,共4页Biological Chemical Engineering

基　　金：2022年湖南省教育厅科学研究项目(湘教通[2022]323号-22C0896)。

摘　　要：目的:制备复方延胡索乙素止痛凝胶(Compound Tetrahydropalmatine Pain Relief Gel,CTPRG),并对其进行质量评价。方法:CTPRG以卡波姆940为基质,将外观、黏度、涂展性、离心稳定性、低温稳定性、高温稳定性作为综合考察指标,采用单因素试验结合正交实验优化处方。结果:所得CTPRG最佳处方为1.00 g卡波姆940,20 g丙二醇,8 g甘油,0.50 g三乙醇胺。产品外观如果冻,表面光滑、均匀、细腻;离心、高温、低温稳定性均良好,无分层、析出药液现象。结论:CTPRG外观良好、质量稳定,研究成果可为元胡止痛方的外用制剂开发利用提供数据基础。Objective:To prepare compound tetrahydropalmatine pain relief gel(CTPRG)and evaluate its quality.Methods:CTPRG is prepared using Carbopol 940 as the matrix,with appearance,viscosity,spread ability,centrifugal stability,low-temperature stability,and high-temperature stability as comprehensive evaluation indicators,and the single factor experiments combined with orthogonal experiments are used to optimize the formulation.Results:The optimal prescription for CTPRG obtained is as follows:1.00 g of Carbopol 940,20 g of propylene glycol,8 g of glycerol,and 0.50 g of triethanolamine.The appearance of the product is like jelly,with a smooth,uniform and delicate surface;the stability of product in centrifugation,high temperature,and low temperature is good,and there is no layering or precipitation of liquid medicine.Conclusion:CTPRG has good appearance,stable quality,and the research results can provide a data basis for the development and utilization of external preparations of Yuanhu Zhitong Formula.

关 键 词：延胡索乙素 凝胶剂 工艺优化 

分 类 号：R283.6[医药卫生—中药学]